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ProteomicsDiscovery of Klf2 Interactors in Mouse Embryonic Stem Cells by Immunoprecipitation-Mass Spectrometry Utilizing Exogenously Expressed Bait
Krüppel-like factor 2 (Klf2) is a DNA-binding transcription factor that regulates embryonic stem cell-specific gene expression. Transcription cofactors such as p300 acetyltransferases and Erk kinases interact with Klf2, providing an additional layer of transcription regulation in embryonic stem cell...
ORGANISM(S): Mus Musculus (mouse) 
2021-09-20 | PXD022123 | JPOST Repository
ProteomicsCD99-mediated immunological synapse formation potentiates CAR-T cell function
Cross-talks between actin and microtubules underly various cellular processes. Using immune synapse model and via cytoskeleton dynamics analyses, here, we demonstrate that CD99 is critical for the actin and microtubule cross-talks and the coordinated reorganization, mediating their physical linkage ...
ORGANISM(S): Mus musculus (Mouse) 
2025-07-18 | PXD039955 | Pride
Immunology Cd99 
ProteomicsHuman skeletal muscle proteome responses to weight loss induced by bariatric surgery or low-calorie diet
Obesity has been linked to lower mitochondrial metabolism in skeletal muscle. Weight loss yields many metabolic advantages, yet the effect of bariatric surgery versus caloric restriction on skeletal muscle mitochondrial metabolism and proteome remains to be elucidated.
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD061410 | Pride
Caloric restriction Low-calorie diet Skeletal muscle Weight loss Bariatric surgery 
ProteomicsPRMT1-mediated methylation regulates MLL2 stability and gene expression
The interplay between multiple transcription factors precisely regulates eukaryotic transcription. Here, we report that the protein methyltransferases, MLL2 and PRMT1, interact directly and act collectively to regulate gene expression. PRMT1 binds to the N-terminal region of MLL2, considered an intr...
ORGANISM(S): Homo Sapiens (human) 
2024-10-21 | PXD055018 | JPOST Repository
UnknownEfficacy of Mobile App-Based Cognitive Behavioral Therapy for Insomnia: Multicenter, Single-Blind Randomized Clinical Trial.
Not available
S-EPMC11316165 | biostudies-literature
UnknownThe genome sequence of the Antarctic bullhead notothen reveals evolutionary adaptations to a cold environment.
Not available
S-EPMC4192396 | biostudies-literature
UnknownEffect of Genetic Diagnosis on Patients with Previously Undiagnosed Disease.
Not available
S-EPMC6481166 | biostudies-literature
UnknownAccurate prediction of protein structures and interactions using a three-track neural network.
Not available
S-EPMC7612213 | biostudies-literature
Unknown<i>De novo</i> design of miniprotein agonists and antagonists targeting G protein-coupled receptors.
Not available
S-EPMC12157396 | biostudies-literature
UnknownModel organisms contribute to diagnosis and discovery in the undiagnosed diseases network: current state and a future vision.
Not available
S-EPMC8103593 | biostudies-literature
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