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TranscriptomicsThe RpoN Regulon of Escherichia coli O157:H7
There is increasing evidence to support a role for sigma factor 54 (RpoN) in the regulation of stress resistance factors and protein secretion systems important to bacterial transmission and pathogenesis. In enterohemorrhagic E. coli O157:H7, acid resistance and type III secretion are essential det...
ORGANISM(S): Escherichia coli O157:H7 str. Sakai 
2009-08-08 | E-GEOD-17467 | biostudies-arrayexpress
MetabolomicsBrown and beige adipose tissue regulate systemic metabolism through a metabolite interorgan signaling axis
Brown and beige adipose tissue are emerging as distinct endocrine organs. These tissues are functionally associated with skeletal muscle, adipose tissue metabolism and systemic energy expenditure, suggesting an interorgan signaling network. Using metabolomics, we identify 3-methyl-2-oxovaleric acid,...
2022-03-03 | MTBLS2436 | MetaboLights
TranscriptomicsMicroRNA-203 represses selection and expansion of oncogenic HRas transformed tumor initiating cells [seq]
In many mouse models of skin cancer, only a few tumors typically form although many cells competent for tumorigenesis receive the same oncogenic mutations. These observations suggest a selection process for defining tumor initiating cells. Here we use quantitative mRNA- and miR-Seq to determine the ...
ORGANISM(S): Mus musculus 
2015-07-23 | E-GEOD-66054 | biostudies-arrayexpress
ProteomicsChemical cross-linking mass spectrometry for systems structural biology in mouse heart tissue.
While modern structural biology technologies have greatly expanded the size and type of protein complexes that can now be studied, the ability to derive large-scale structural information on proteins and complexes as they exist within tissues is practically non-existent. Many protein properties and...
ORGANISM(S): Mus musculus (Mouse) 
2017-11-30 | PXD007673 | Pride
Mass spectrometry Structural biology Mouse Heart Protein-protein interactions Cross-linking 
UnknownPhase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression.
Not available
S-EPMC3157965 | biostudies-literature
UnknownPhase II study of the safety and antitumor activity of the hypoxia-activated prodrug TH-302 in combination with doxorubicin in patients with advanced soft tissue sarcoma.
Not available
S-EPMC4588714 | biostudies-literature
UnknownHypoxia-Related Radiomics and Immunotherapy Response: A Multicohort Study of Non-Small Cell Lung Cancer.
Not available
S-EPMC8363765 | biostudies-literature
ProteomicsIn vivo protein interaction network analysis reveals porin-localized toxin inactivation in antibiotic resistant bacteria
The nosocomial pathogen Acinetobacter baumannii is a frequent cause of hospital acquired infections worldwide, and a challenge for treatment due to its evolved resistance to antibiotics, including carbapenems. To gain insight on A. baumannii antibiotic resistance mechanisms, we analyzed the protein...
ORGANISM(S): Acinetobacter baumannii AB5075 
2016-12-22 | PXD004236 | Pride
Acinetobacter baumannii Chemical cross-linking Protein-protein interactions Antibiotic resistance Carbapenem 
UnknownEffects of a brief multimedia psychoeducational intervention on the attitudes and interest of patients with cancer regarding clinical trial participation: a multicenter randomized controlled trial.
Not available
S-EPMC4577714 | biostudies-literature
TranscriptomicsXist RNA is a potent suppressor of hematologic cancer in mice.
X-chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X-chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate tha...
ORGANISM(S): Mus musculus 
2013-02-20 | E-GEOD-43961 | biostudies-arrayexpress
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