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ProteomicsProteomic analysis of Prote-a-Tac
The 26S proteasome recognizes substrates via ubiquitin receptors, a mechanism we leveraged to develop a small molecule ligand- and ubiquitination-independent targeted protein degradation strategy. Our proteasome-targeting chimera, Prote-a-Tac, links a proteasomal Ub receptor (PSMD4 or ADRM1) with a ...
ORGANISM(S): Homo sapiens (Human) 
2026-07-06 | PXD063133 | Pride
Tmt Degradation Proteasome 
ProteomicsComprehensive and Unbiased Plasma Proteomics with Proteograph
Mild Cognitive Impairment (MCI) is a precursor to Alzheimer's disease (AD), necessitating early identification through reliable markers. We employed ProteographTM, an automated platform utilizing nanoparticles coupled with a liquid chromatography-tandem mass spectrometry (LC-MS/MS) workflow, enablin...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD067951 | Pride
Proteograph Mild cognitive impairment Human plasma 
ProteomicsCTCF cooperates with CtIP to drive homologous recombination repair of double-strand breaks
The pleiotropic CCCTC-binding factor (CTCF) plays a role in homologous recombination (HR) repair of DNA double-strand breaks (DSBs). However, the precise mechanistic role of CTCF in HR remains largely unclear. Here, we show that CTCF engages in DNA end resection, which is the initial, crucial step i...
ORGANISM(S): Homo sapiens (Human) 
2019-11-12 | PXD014441 | Pride
Pleiotropic ccctc-binding factor Mre11 Human Interactome 
UnknownPyuria as an independent predictor of intravesical recurrence after radical nephroureterectomy in patients with upper tract urothelial carcinoma.
Not available
S-EPMC10330412 | biostudies-literature
UnknownExcitability-Independent Memory Allocation for Repeated Event.
Not available
S-EPMC9094695 | biostudies-literature
UnknownUltra-Mild Fabrication of Highly Concentrated SWCNT Dispersion Using Spontaneous Charging in Solvated Electron System.
Not available
S-EPMC11243719 | biostudies-literature
UnknownSynthesis of silver nanoparticles embedded with single-walled carbon nanotubes for printable elastic electrodes and sensors with high stability.
Not available
S-EPMC7933232 | biostudies-literature
UnknownModulation of Inducible Nitric Oxide Synthase Expression in LPS-Stimulated BV-2 Microglia by Prenylated Chalcones from Cullen corylifolium (L.) Medik. through Inhibition of I-κBα Degradation.
Not available
S-EPMC6017879 | biostudies-literature
UnknownNatal factors affecting developmental defects of enamel in preterm infants: a prospective cohort study.
Not available
S-EPMC10808204 | biostudies-literature
UnknownNeuroprotective Effect of Nortriptyline in Overt Hepatic Encephalopathy Through Attenuation of Mitochondrial Dysfunction.
Not available
S-EPMC6238202 | biostudies-literature
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