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UnknownPhase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein.

Purpose

Multiple myeloma (MM) is an incurable plasma-cell neoplasm for which most treatments involve a therapeutic agent combined with dexamethasone. The preclinical combination of lenalidomide with the mTOR inhibitor CCI-779 has displayed synergy in vitro and represents a novel combination ...
S-EPMC3164245 | biostudies-literature
UnknownSustained expression of unc-4 homeobox gene and unc-37/Groucho in postmitotic neurons specifies the spatial organization of the cholinergic synapses in C. elegans.
Neuronal cell fate determinants establish the identities of neurons by controlling gene expression to regulate neuronal morphology and synaptic connectivity. However, it is not understood if neuronal cell fate determinants have postmitotic functions in synapse pattern formation. Here we identify a n...
S-EPMC8363302 | biostudies-literature
UnknownDeterminants of cord blood adipokines and association with neonatal abdominal adipose tissue distribution.

Background

Cord blood leptin and adiponectin are adipokines known to be associated with birth weight and overall infant adiposity. However, few studies have investigated their associations with abdominal adiposity in neonates. We examined maternal factors associated with cord blood leptin an...
S-EPMC8873009 | biostudies-literature
TranscriptomicsTranscription profiling of Arabidopsis treated with sugars (glucose, mannose) and abcissic acid
The aim of the experiment is to determine sugar and ABA responsive gene expression in Arabidopsis.
ORGANISM(S): Arabidopsis thaliana 
2005-10-01 | E-MEXP-475 | biostudies-arrayexpress
UnknownAutomated Segmentation of Visceral, Deep Subcutaneous, and Superficial Subcutaneous Adipose Tissue Volumes in MRI of Neonates and Young Children.

Purpose

To develop and evaluate an automated segmentation method for accurate quantification of abdominal adipose tissue (AAT) depots (superficial subcutaneous adipose tissue [SSAT], deep subcutaneous adipose tissue [DSAT], and visceral adipose tissue [VAT]) in neonates and young children.
S-EPMC8489452 | biostudies-literature
UnknownSexual dimorphism in the association of umbilical cord blood lipidome with abdominal fat in early childhood.

Background

Although the associations between cord blood lipidome and neonatal birth weight are established, it remains uncertain whether sexual dimorphism in fetal fat accumulation extends to the relationship between cord blood lipid profiles and neonatal abdominal fat compartments. Understa...
S-EPMC11995507 | biostudies-literature
UnknownLongitudinal characterization of determinants associated with obesogenic growth patterns in early childhood.

Background

Longitudinal assessment of the determinants of obesogenic growth trajectories in childhood can suggest appropriate developmental windows for intervention.

Methods

Latent class growth mixture modelling was used to identify body mass index (BMI) z-score trajectories from birt...
S-EPMC10114026 | biostudies-literature
UnknownMismatch between poor fetal growth and rapid postnatal weight gain in the first 2 years of life is associated with higher blood pressure and insulin resistance without increased adiposity in childhood: the GUSTO cohort study.

Background

Using longitudinal ultrasounds as an improved fetal growth marker, we aimed to investigate if fetal growth deceleration followed by rapid postnatal weight gain is associated with childhood cardiometabolic risk biomarkers in a contemporary well-nourished population.

Methods

...
S-EPMC7116531 | biostudies-literature
UnknownIntranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice.
The emergence of new immune-evasive severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants and subvariants outpaces the development of vaccines specific against the dominant circulating strains. In terms of the only accepted immune correlate of protection, the inactivated whole-virion...
S-EPMC10052291 | biostudies-literature
UnknownCohort profile: Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO).
The Singapore Preconception Study of Long-Term Maternal and Child Outcomes (S-PRESTO) is a preconception, longitudinal cohort study that aims to study the effects of nutrition, lifestyle, and maternal mood prior to and during pregnancy on the epigenome of the offspring and clinically important outco...
S-EPMC7116651 | biostudies-literature
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