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TranscriptomicsChemical modifications mark alternatively spliced and actively degrading messenger RNAs in Arabidopsis and humans
Post-transcriptional chemical modification of RNA bases is a widespread and physiologically relevant regulator of RNA maturation, stability, and function. While modifications are best characterized in short, noncoding RNAs such as transfer RNAs (tRNAs), growing evidence indicates that messenger RNAs...
ORGANISM(S): Homo sapiens 
2015-10-31 | E-GEOD-66224 | biostudies-arrayexpress
UnknownA sterile insect technique pilot trial on Captiva Island: defining mosquito population parameters for sterile male releases using mark-release-recapture.
Not available
S-EPMC9628054 | biostudies-literature
GenomicsX-chromosome hyperactivation in mammals via nonlinear relationships between chromatin states and transcription
Dosage compensation in mammals occurs at two levels. In addition to balancing X-chromosome dosage between males and females via X-inactivation, mammals also balance dosage of Xs and autosomes. It has been proposed that X-autosome equalization occurs by upregulation of Xa (active X). To investigate t...
ORGANISM(S): Mus musculus 
2012-01-06 | E-GEOD-33823 | biostudies-arrayexpress
TranscriptomicsEnhancer Transcripts Mark Active Estrogen Receptor Binding Sites
In this study, we used Global Run-On sequencing (GRO-seq), a method that assays the genome-wide location and orientation of all active RNA polymerases. We generated a global profile of active transcription at ERM-NM-1 binding sites in MCF-7 human breast cancer cells in response to short time course ...
ORGANISM(S): Homo sapiens 
2013-05-08 | E-GEOD-43835 | biostudies-arrayexpress
TranscriptomicsZMYND8 reads the dual histone mark H3K4me1-H3K14ac to antagonize the expression of metastasis-linked genes
Histone acetylation, including acetylated H3K14 (H3K14ac), is generally linked to gene activation. Monomethylated histone H3 lysine 4 (H3K4me1), together with other gene-activating marks, denotes active genes. In contrast to usual gene-activating functions of H3K14ac and H3K4me1, we here show that t...
ORGANISM(S): Homo sapiens 
2016-07-28 | E-GEOD-82260 | biostudies-arrayexpress
TranscriptomicsEnhancer Transcripts Mark Active Estrogen Receptor Binding Sites using GRO-seq
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-28 | E-GEOD-43836 | biostudies-arrayexpress
UnknownHNRNPA2B1 Is a Mediator of m(6)A-Dependent Nuclear RNA Processing Events.
Not available
S-EPMC4673968 | biostudies-literature
TranscriptomicsChromatin immunoprecipitation of wild type, SET2 deletion, Rco1 PHD domain deletion and Eaf3 chromodomain deletion yeast using anti-acetyl-histone H4
Nucleosomes must be deacetylated behind elongating RNA polymerase II to prevent cryptic initiation of transcription within the coding region. RNA polymerase II signals for deacetylation through methylation of histone H3 lysine 36 (H3K36) which provides the recruitment signal for the Rpd3S deacetylas...
ORGANISM(S): Saccharomyces cerevisiae 
2007-05-16 | E-TABM-260 | biostudies-arrayexpress
UnknownFemale Estrogen-Related Factors and Incidence of Basal Cell Carcinoma in a Nationwide US Cohort.
Not available
S-EPMC4669591 | biostudies-literature
GenomicsDynamics of Genomic H3K27me3 Domains and Role of EZH2 during Pancreatic Endocrine Specification
Endoderm cells undergo a sequence of fate choices to generate insulin-secreting M-NM-2 cells. Studies of chromatin transitions during this process have been limited to the pancreatic progenitor stage that can be reconstituted from stem cells in vitro, with a gap in understanding the induction of end...
ORGANISM(S): Mus musculus 
2014-07-28 | E-GEOD-56617 | biostudies-arrayexpress
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