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ProteomicsExploration on survived mice after sepsis and proteomic analy-sis on LPS-activated macrophages supports the regulation of sepsis hyper-inflammation by intravenous immunoglobulin
Because the immune regulation in survivor after sepsis (an immune dysregulation from severe infection) might be applied for treatment, survivors and moribund mice after cecal liga-tion and puncture (CLP) and in vitro experiments on macrophages were explored. Most of the parameters in survivors (5-da...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-22 | PXD027471 | Pride
Sepsis  clp  macrophages  proteomic analysis  ivig 
ProteomicsThe regulatory roles of Ezh2 in response to lipopolysaccharide (LPS) in macrophages and mice with conditional Ezh2 deletion with LysM-Cre system
The responses of macrophages to lipopolysaccharide (LPS) might determine the direction of clinical manifestations of sepsis, which is the immune response against severe infection. Meanwhile, the enhancer of zeste homologue 2 (Ezh2), a histone lysine methyltransferase of epigenetic regulation, might ...
ORGANISM(S): Mus musculus (Mouse) 
2023-07-20 | PXD041265 | Pride
Lipopolysaccharide Macrophage Epigenetics Ezh2 Sepsis 
ProteomicsThe architecture and pathogenesis of Pseudomonas-Candida biofilms in infections and their influence on the microenvironment
Interkingdom Pseudomonas-Candida biofilms is a human pathogen associated with acute and chronic infection. This study examine hoe their structural organization influences their in vivo microenvironment, which in turns affects the interaction of Pseudomonas-Candida biofilms with host immune responses...
ORGANISM(S): Candida albicans (Yeast) 
2022-10-13 | PXD034528 | Pride
Pseudompnas aeruginosa Interkingdom biofilms Pneumonia Candida albicans 
ProteomicsChlorhexidine promotes psl in Pseudomonas aeruginosa that enhances cell aggregation with preserved pathogenicity demonstrates an adaptation against antiseptic
Because Pseudomonas aeruginosa is a common pathogen that frequently contacts with Chlorhexidine digluconate (a regular antiseptic), then adaptations against Chlorhexidine were tested. In com-parison with the parent strain, the Chlorhexidine-adapted strain formed smaller colonies with the downregulat...
ORGANISM(S): Homo sapiens (Human) 
2022-10-14 | PXD034530 | Pride
Pseudomonas aeruginosa  chlorhexidine digluconate  chlorhexidine  cross-resistance  biofilm  psl  cell aggregate  persistence  wound infection 
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