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MetabolomicsUntargeted Plasma Lipidomics Identifies Oxidative Stress and Inflammation Signatures Associated with Recurrent Leg Ulcer Status in Sickle Cell Disease

Leg ulcers are among the most burdensome complications of sickle cell disease (SCD), yet the molecular determinants underlying ulcer susceptibility and recurrence remain incompletely characterized. We performed untargeted plasma lipidomics by LC–MS in 129 individuals with SCD from the REDS-III Br...

2025-12-19 | MTBLS13538 | MetaboLights
TranscriptomicsTranscription profiling of normal adult rat extraocular muscle, cardiac muscle, leg (gastrocnemius-soleus) muscle and smooth muscle (stomach wall)
Comparison of normal adult rat extraocular muscle, cardiac muscle, leg (gastrocnemius-soleus) muscle and smooth muscle (stomach wall). Affymetrix microarray chip RG-U34A was used. MAS version 5 was used to analyze the muscle group differences. Data form part of publication: FASEB Journal 17: 1370-...
ORGANISM(S): Rattus norvegicus 
2007-10-27 | E-GEOD-142 | biostudies-arrayexpress
ProteomicsProteomic comparison of breast, leg, and thigh meat from turkey (Meleagris gallopavo)
The proteomes of breast, leg, and thigh meat from turkey were compared using label-free methods.
ORGANISM(S): Meleagris gallopavo (Common turkey) 
2017-11-27 | PXD008207 | Pride
Turkey Meleagris gallopavo Breast Thigh Leg Proteome 
ProteomicsLongitudinal evaluation of biomarkers in wound fluids of venous leg ulcers treated with a protease-modulating wound dressing
Venous leg ulcers (VLU) represent a clinical challenge and impair the patient’s quality of life. Venous insufficiency is underlying the protracted healing. We report the protein expression pattern for biomarkers in VLU wound fluids and compare these with acute split-thickness wound fluids. Fifty-se...
ORGANISM(S): Homo Sapiens 
2023-08-22 | PXD025748 | panorama
TranscriptomicsSingle-cell RNA-Seq of leg disc mesodermal precursors labeled with GFP at five developmental stages
This study investigates how spatial and temporal signaling cues orchestrate the specification of mesodermal progenitors into distinct leg muscle lineages in Drosophila. Using single-cell RNA sequencing across developmental stages, we show that mesodermal precursors initially segregate into central a...
ORGANISM(S): Drosophila melanogaster 
2026-03-17 | E-MTAB-16520 | biostudies-arrayexpress
TranscriptomicsCTCF binding profiles in Drosophila melanogaster 3rd instar larva T1 and T3 leg discs
Although the majority of genomic binding sites for the insulator protein CTCF are constitutively occupied, a subset show variable occupancy. Such variable sites provide an opportunity to assess context-specific CTCF functions in gene regulation. Here we have identified a variably occupied CTCF site ...
ORGANISM(S): Drosophila melanogaster 
2014-10-11 | E-GEOD-62234 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of adult wild-type IFM and leg muslce in comparison to salm RNAi IFM.
Transcriptional profiling comparing adult wild-type indirect flight muscle (IFM) with wild-type leg muscle and salm RNAi IFM (Mef2-GAL4, UASsalmIR). We used 2 different salm hairpin constructs for the experiments, TF3029 and TF101052, both available from the VDRC Drosophila stock centre. Experiments...
ORGANISM(S): Drosophila melanogaster 
2011-03-01 | E-GEOD-27502 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leg muscle subjected to different exercise regimens
The study has been described in the following paper: Gianni Parise, Stuart M. Phillips, Jan J. Kaczor and Mark A. Tarnopolsky (2005). Antioxidant enzyme activity is up-regulated after unilateral resistance exercise training in older adults. Free Radical Biology and Medicine, Volume 39, Issue 2, 15 ...
ORGANISM(S): Homo sapiens 
2007-06-07 | E-MEXP-740 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat rear leg muscle from normal and diabetic subjects treated with vanadyl sulfate
RNA was obtained from rear leg muscle of normal and diabetic rats in the presence and absence of oral treatment with vanadyl sulfate. Diabetes was induced with streptozotocin and expression profiles were determined using Affymetrix Rat Genechip U34A. The effect of treatment and disease on gene expr...
ORGANISM(S): Rattus norvegicus 
2007-11-06 | E-GEOD-3068 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human vastus lateralis muscle from exercised and non-exercised subjects
Four healthy human volunteers underwent an acute bout of resistance exercise with the right leg at 2 pm. Biopsies were removed from the Vastus Lateralis muscle 6 h (8 pm) and 18 h (8 am) after exericise
ORGANISM(S): Homo sapiens 
2007-08-21 | E-GEOD-1832 | biostudies-arrayexpress
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