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TranscriptomicsIntracellular expression pattern of recombinant Mtb strain TB294 overexpressing sigma factor A
We previously showed that increased expression of the principal sigma factor, SigA, mediates the capacity of Mycobacterium tuberculosis 210 strains to grow more rapidly in human monocytes, compared to other strains. To identify SigA-regulated genes that favor intracellular mycobacterial growth, we u...
ORGANISM(S): Mycobacterium tuberculosis 
2010-10-08 | E-GEOD-13780 | biostudies-arrayexpress
UnknownMCL1 modulates mTORC1 signaling to promote bioenergetics and tumorigenesis.
Not available
S-EPMC12673096 | biostudies-literature
TranscriptomicsCard9 dependent activation of macrophages by TDB
Bone marrow derived macrophages from wt and card9 KO mice were stimulated with CpG, Curdlan or TDB, an analogon to the mycobacterial cord factor TDM for 48h, respectively. Keywords: card9 knockout, macropphage, TDB wt or card9 KO macrophages stimulated for 48h
ORGANISM(S): Mus musculus 
2009-01-31 | E-GEOD-10530 | biostudies-arrayexpress
TranscriptomicsDNA Methylation of gDNA from blood and bronchoalveolar lavage of tuburbulosis patients with and without type 2 diabetes via Illumina Infinium MethylationEPIC array
Tuberculosis (TB) remains a leading cause of illness and death globally. Type 2 diabetes (T2D) patients are more likely to become infected with Mycobacterium tuberculosis (M.tb). When they are infected, they are more likely to develop active TB disease and to present with more severe TB and those wh...
ORGANISM(S): Homo sapiens 
2025-12-14 | E-MTAB-16151 | biostudies-arrayexpress
UnknownSingle-cell landscape of innate and acquired drug resistance in acute myeloid leukemia.
Not available
S-EPMC11525670 | biostudies-literature
TranscriptomicsCholesterol's effect on M. tuberculosis
2 experiments: (1) Mtb, Tween vs Cholesterol at 3 & 24hrs (2) CDC1551 vs kstR mutant of CDC1551, with and w/o Cholesterol In triplicate, dye flips included.
ORGANISM(S): Mycobacterium tuberculosis 
2010-06-20 | E-GEOD-13978 | biostudies-arrayexpress
TranscriptomicsTranscriptional analysis of RelE family toxin overexpression in Mycobacterium tuberculosis
To understand the mechanism of action of the RelE family of toxins on metabolism of Mycobacterium tuberculosis. To this effect, toxin expression was induced under control of a tetracycline regulatable promoter and transcriptional profiles compared during overexpression of the three RelE toxin family...
ORGANISM(S): Mycobacterium tuberculosis 
2010-05-18 | E-GEOD-13998 | biostudies-arrayexpress
TranscriptomicsMntR(Rv2788): a transcriptional regulator that controls manganese homeostasis in Mycobacterium tuberculosis.
Transcriptional profiling of SirR and manganese regulated expression of genes in Mycobacterium tuberculosis strains comparing high manganese vs. low manganese in Rv (wild type Mycobacterium tuberculosis) and ST70 (mntR mutant strain of Mycobacterium tuberculosis) Two strains each with two conditions...
ORGANISM(S): Mycobacterium tuberculosis 
2015-12-08 | E-GEOD-70812 | biostudies-arrayexpress
TranscriptomicsComparative transcriptomic analysis of human macrophages during Mycobacterium avium versus Mycobacterium tuberculosis infection
The treatment of Mycobacterium avium (Mav) infection, responsible for over 80% of non-tuberculous mycobacterial pulmonary disease, remains challenging due to rising antibiotic resistance and unsatisfactory success rates. Hence, there is a need for a deeper understanding of host–pathogen interaction...
ORGANISM(S): Homo sapiens 
2026-01-16 | E-MTAB-15473 | biostudies-arrayexpress
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