Comparative transcriptomic analysis of human macrophages during Mycobacterium avium versus Mycobacterium tuberculosis infection

ABSTRACT: The treatment of Mycobacterium avium (Mav) infection, responsible for over 80% of non-tuberculous mycobacterial pulmonary disease, remains challenging due to rising antibiotic resistance and unsatisfactory success rates. Hence, there is a need for a deeper understanding of host–pathogen interactions to inform the development of alternative therapeutic approaches, like host-directed therapy (HDT), aimed at improving host antimycobacterial defenses.. However, compared to Mycobacterium tuberculosis (Mtb) infections, knowledge of host-pathogen interactions for Mav infection is still limited. To address this knowledge gap, we performed a genome-wide host transcriptomic analysis of Mav-infected primary human macrophages —the primary host cell—alongside Mtb-infected macrophages to leverage insig

INSTRUMENT(S): Illumina NovaSeq 6000

ORGANISM(S): Homo sapiens

SUBMITTER: Leon Mei 

PROVIDER: E-MTAB-15473 | biostudies-arrayexpress |

REPOSITORIES: biostudies-arrayexpress