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ProteomicsPhosphoproteomics analysis of CHK1 inhibitor treatment
Inhibitors of checkpoint kinase 1 (CHK1),a central component of DNA damage and cell cycle checkpoint response, represent a promising new cancer therapy, but the global cellular functionsthey regulate through phosphorylationare poorly understood. To elucidate the CHK1-regulated phosphorylation networ...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD015125 | Pride
Chk1 inhibitor Silac Phosphoprotomics 
ProteomicsProteomic profiles of Rat Pancreatic Islets
In this study, we achieved integrated transcriptomic and proteomic profiles of GK islets in a time-course fashion at different stages of T2D. Subsequent bioinformatics analysis revealed the chronological order of T2D-related molecular events during the deterioration of pancreatic islets. Our large q...
ORGANISM(S): Rattus norvegicus (Rat) 
2017-06-02 | PXD004709 | Pride
Rat islets proteome 
ProteomicsGlobal Phosphoproteomic Analysis Reveals ARMC10 as an AMPK Substrate that Regulates Mitochondrial Dynamics
AMP-activated protein kinase (AMPK) is a key regulator of cellular energy homeostasis. Although AMPK has been studied extensively in cellular processes, understanding of its substrates and downstream functional network, and their contributions to cell fate and disease development, remains incomplete...
ORGANISM(S): Homo sapiens (Human) 
2019-01-16 | PXD011696 | Pride
Phosphoproteomics Ampk Silac Lc-ms/ms 
ProteomicsIdentification of ANXA1 as A Novel Upstream Negative Regulator of Notch1 Function in AML
Abnormal Notch1 expression has an important role in tumorigenesis. However, upstream control mechanisms for Notch1 are still insufficiently understood. Acute myeloid leukemia (AML) is one of the most common and lethal blood malignancies with limited possibilities for treatment. Thus, new therapeutic...
ORGANISM(S): Homo Sapiens 
2024-10-03 | PXD056593 |
ProteomicsMass spectrometry with DIA quantification of cerebrospinal fluid in 20 subarachnoid hemorrhage patients
We applied mass spectrometry with DIA quantification to identify biomarker candidates in CSF samples from a well-characterized cohort consisted of 20 SAH patients.
ORGANISM(S): Human Csf-associated Densovirus 
2022-03-08 | PXD032118 |
MetabolomicsAberrant gut microbiota alters host metabolome and impacts renal failure in humans and rodents

OBJECTIVE: Patients with renal failure suffer from symptoms caused by uraemic toxins, possibly of gut microbial origin, as deduced from studies in animals. The aim of the study is to characterise relationships between the intestinal microbiome composition, uraemic toxins and rena...

2020-10-20 | MTBLS700 | MetaboLights
ProteomicsLow-dose metformin targets the lysosome-AMPK pathway through PEN2
Metformin is the most prescribed anti-diabetic medicine, and has also been shown to have other various benefits, such as anti-aging and anti-cancer effects. For clinical doses of metformin, it is known that AMPK plays a major role; however, the direct molecular target of metformin remains unclear. H...
ORGANISM(S): Homo Sapiens Mus Musculus 
2021-12-01 | PXD030090 |
ProteomicsThe aldolase inhibitor aldometanib mimics glucose starvation to activate lysosomal AMPK
The activity of 5’-adenosine monophosphate-activated protein kinase (AMPK) is inversely correlated with the cellular availability of glucose. When glucose levels are low, the glycolytic enzyme aldolase is not bound to fructose-1,6-bisphosphate (FBP) and, instead, signals to activate lysosomal AMPK. ...
ORGANISM(S): Oryctolagus Cuniculus 
2022-08-10 | PXD035968 |
UnknownUsing CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Not available
S-EPMC3150628 | biostudies-literature
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