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ProteomicsA nature-inspired nanoplatform for multiple targeted proteins degradation via autophagy-lysosome pathway
This project primarily investigates the interactome of SNX18, a key mediator protein in the degradation of extracellular vesicles (EVs), as well as the degradation efficiency of EGFR and PDL1 using an SNX18-LIR motif-based overexpression platform for targeted protein degradation.
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072326 |
Proteomics2022-0222-SK cell line infected by ZIKV（MR766,PRVABC.59)-1044
In this project, mass spectrometer Q-Exactive HF X was used. Total number of 43898 spectra were obtained from the sample group SK_mock. After identification by search engine, 6733 spectra were matched, 1094 proteins and 5074 peptides were identified.Total number of 46943 spectra were obtained from t...
ORGANISM(S): Homo Sapiens 
2024-03-25 | PXD050964 |
ProteomicsIdentification of antiviral RNAi regulators, ILF3/DHX9, recruit at ZIKV stem loop B to protect against ZIKV induced microcephaly
The stained gel bands are washed three times with ddH2O, followed by the addition of 150μL of destaining solution to remove the stain. After four rounds of water washing, the gel bands are washed twice with 300μL each of 25mM ammonium bicarbonate, 50% acetonitrile, and 100% acetonitrile, respectivel...
ORGANISM(S): Homo Sapiens 
2024-08-14 | PXD054904 |
ProteomicsSystematic discovery of linear ubiquitination mediated neo-protein-protein interactions across mouse tissues
HOIP truncations proteins GST-PUB, GST-NZF, GST-UBA and GST-RBR-LDD were purified, GST was used as a negative control. The tissue lysates from the C57BL/6 mice were incubated with glutathione-S-transferase (GST) beads which bound to the GST-HOIP truncation proteins beforehand. The pull-down componen...
ORGANISM(S): Mus Musculus 
2024-02-28 | PXD043322 |
ProteomicsGlobal identification ofphospho-dependent SCF ubiquitin ligase substrate reveal a role of ERK-FBXO22-BAG3 axis in tumorigenesis
293T cells were cultured in SILAC medium. Heavy group was labeled with K6&R10. Light group was labeled with K0&R0. In light group, cells were treated with MLN4924. In heavy group, cells were treated with DMSO. Then cells were lysed, mixed and tryptic digested. Peptide mixture was subjected to phosph...
ORGANISM(S): Homo Sapiens 
2021-06-29 | PXD027020 |
ProteomicsIntegrative proteomic characterization of human lung adenocarcinoma
Genomic studies of lung adenocarcinoma (LUAD) have advanced understanding of the disease’s biology and accelerated targeted therapy. However, proteomic characteristics of LUAD remain poorly understood. We carried out comprehensive proteomic analysis of 103 cases of LUAD in Chinese patients. Integrat...
ORGANISM(S): Homo Sapiens 
2020-07-10 | PXD020252 |
ProteomicsA Recombinant Vaccine Targeting Receptor-binding Domain of SARS-CoV-2 Spike Protein Induces Protective Immunity in Mice and Non-human Primates
The novel Coronavirus SARS-CoV-2 causes a respiratory illness called COVID-19 leading to a pandemic. An effective preventive vaccine against this virus is urgently needed.
ORGANISM(S): Severe Acute Respiratory Syndrome Coronavirus 2 
2020-07-30 | PXD020653 |
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