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TranscriptomicsKinetoplastid-specific histone variant functions are conserved in Leishmania major
Protein-coding genes in kinetoplastid protists are transcribed from polycistronic arrays, yielding RNA precursors which are processed to form mature transcripts bearing a 5M-bM-^@M-^Y spliced leader (SL) and 3M-bM-^@M-^Y poly(A) tract. Regions of transcription initiation and termination lack known e...
ORGANISM(S): Leishmania major 
2013-10-26 | E-GEOD-51737 | biostudies-arrayexpress
ProteomicsHILIC enrichment of Leishmania major MHOM
The trypanosomatid protozoan parasite Leishmania has a significant impact on human health globally. Understanding the pathways associated with virulence within this significant pathogen is critical for identifying novel vaccination and chemotherapy targets. Within this study we leverage an ultradeep...
ORGANISM(S): Leishmania major species complex 
2022-10-13 | PXD035738 | Pride
Leishmania major mhom Glycopeptides 
MetabolomicsTranscriptional Shift and Metabolic Adaptations during Leishmania Quiescence Using Stationary Phase and Drug Pressure as Models

Microorganisms can adopt a quiescent physiological condition which acts as a survival strategy under unfavourable conditions. Quiescent cells are characterized by slow or non-proliferation and deep down-regulation of processes related to biosynthesis. Although quiescence has been described mostly...

2022-02-23 | MTBLS4046 | MetaboLights
TranscriptomicsSimultaneous gene expression profiling in human macrophages infected with Leishmania major parasites using SAGE
Leishmania (L) are intracellular protozoan parasites which are able to survive and replicate within the harsh and potentially hostile phago-lysosomal environment of mammalian mononuclear phagocytes. A complex interplay then takes place between the macrophage (MM-NM-&) striving to eliminate the patho...
ORGANISM(S): Leishmania major 
2008-05-21 | E-GEOD-10442 | biostudies-arrayexpress
TranscriptomicsLeishmania major modulates autophagy in host macrophages during intracellular differentiation
Autophagy generally participates in innate immunity by elimination of intracellular pathogens. However, many of them developed successful strategies to counteract their autolysosomal digestion and lastly to exploit this catabolic cellular process. Protozoan parasites of the genus Leishmania are the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-52624 | biostudies-arrayexpress
TranscriptomicsLeishmania major infection-induced changes in the small RNA transcriptome of host macrophages.
Protozoan parasites of the genus Leishmania are the causative agent of leishmaniasis, one of the 13 most important tropical diseases. Leishmania persists as endo-parasite in host macrophages, where it uses multiple strategies to manipulate the microbicidal host cell functions and to escape from the ...
ORGANISM(S): Mus musculus 
2015-08-03 | E-GEOD-58369 | biostudies-arrayexpress
GenomicsLeishmania major strain:MHOM/SN/74/SD
Leishmania major SD75 Genome Sequencing
PRJNA165887 | ENA
GenomicsLeishmania major strain:Friedlin V1 (MHOM/IL/1980/Friedlin)
Leishmania major transcriptome
PRJNA252769 | ENA
GenomicsLeishmania major strain:Friedlin V1 (MHOM/IL/1980/Friedlin)
Leishmania major ribosome profiling
PRJNA243836 | ENA
ProteomicsDeep proteome analysis of Leishmania major Friedlin
Deep proteome analysis to assess the impact of FUT1 and LPG on the L. major Friedlin proteome
ORGANISM(S): Leishmania major strain Friedlin 
2022-10-12 | PXD015966 | Pride
Leishmania Deep proteome analysis 
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