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Across the spectrum of human disease there are significant changes in the composition and organisation of extracellular matrix (ECM). Furthermore, disease severity can vary according to race and sex, yet mechanisms for these variations are unclear. Using the kidney glomerulus as a model system, we t...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-09 | PXD000811 | Pride
Basement membranes (BMs) are ubiquitous extracellular matrices whose composition remains elusive, limiting our understanding of BM regulation and function. By developing a bioinformatic and in vivo discovery pipeline, we define a network of over 220 human proteins localized to BMs. More than 100 BM-...
ORGANISM(S): Homo sapiens (Human) 
2022-05-31 | PXD029266 | Pride
The glomerular basement membrane has a complex composition and structure in vivo. In vitro models of the glomerular capillary wall have been developed using microfluidic and perfusion systems, however, how the extracellular matrix alters under static and flow conditions has not yet been investigate...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD044226 | Pride
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