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MetabolomicsDelayed molecular aging, preservation of energy metabolism and enhanced exercise response in exercise-trained human muscle

Exercise is fundamental to healthy aging, yet the degree to which it mitigates age-related molecular changes and how varying physical fitness levels influence the molecular response to exercise with age remain unclear. To address this, we performed transcriptomics, lipidomics, and metabolomics on...

2026-04-09 | MTBLS12824 | MetaboLights
MetabolomicsPeripheral modulation of antidepressant targets MAO-B and GABAAR by harmol induces mitohormesis and delays aging in preclinical models
Reversible and sub-lethal stresses to the mitochondria elicit a program of compensatory responses that ultimately improve mitochondrial function, a conserved anti-aging mechanism termed mitohormesis. Here, we show that harmol, a member of the beta-carbolines family with anti-depressant properties, i...
2023-05-26 | MTBLS7533 | MetaboLights
ProteomicsDehydroalanine and Dehydrobutyrine in Aging and Cataractous Lenses
Protein post-translational modifications (PTMs) have been associated with aging and age-related diseases. PTMs are particularly impactful in long-lived proteins, such as those found in the ocular lens, because they accumulate with age. Two post-translational modifications that lead to protein-protei...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD045734 | Pride
Dehydrobutyrine Aging Dehydroalanine Lens Cataracts 
ProteomicsData-independent acquisition parallel accumulation-serial fragmentation (diaPASEF) analysis of the separated zebrafish lens improves identifications
Ocular lens fiber cells degrade their organelles during differentiation to prevent light scattering. Organelle degradation occurs continuously throughout an individual’s lifespan, creating a spatial gradient of young cortical fiber cells in the lens periphery to older nuclear fiber cells in the cent...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) 
2025-03-20 | PXD059560 | Pride
Dia Lens Diapasef Zebrafish Aging 
ProteomicsProteomic Characterization of the Rhesus Macaque Lens Nucleus: Similarity to Human Lens, Age Effects on Protein Solubility, and Trends in Posttranslational Modification
Proteomes of lens nuclei from young (4 years old) and old (15-16 years old) rhesus macaques (Macaca mulatta) were analyzed to determine similarity of the proteomic profile to that of human lenses, age-related differences in protein solubility, and association of various posttranslational modificatio...
ORGANISM(S): Macaca mulatta (Rhesus macaque) 
2025-09-16 | PXD062952 | Pride
Non-human primates Post-translational modifications Mass spectrometry Eye lens Rhesus macaque Quantitative proteomics Aging 
ProteomicsAge-related cleavages of crystallins in human lens cortical fibre cells generate a plethora of endogenous peptides and high molecular weight complexes
Age-related breakdown of lenticular crystallins is associated with lenticular disorders such as cataract. Despite playing a critical role in maintaining lens homeostasis, the mechanism(s) and consequences of this phenomenon are not well understood. Utilising a proteomic-based approach, this study ch...
ORGANISM(S): Homo sapiens (Human) 
2016-09-29 | PXD001630 | Pride
Lens aging  crystallin  cataract  mass spectrometry  endogenous peptides  2-d gel electrophoresis  nanolc-esi-ms/ms  trypsin-like cleavage. 
MetabolomicsMulti-omics insights into the formation mechanism of aging quality in white tea (Bai Mudan) during storage: integrating sensory evaluation, volatilomics, metabolomics, and metagenomics

White tea (WT) develops unique aged quality during long-term storage, characterized by progressive changes in sensory properties and chemical composition. However, integrated insights into the sensory, metabolites, and microbial contribution underlying this...

2025-11-18 | MTBLS13336 | MetaboLights
GenomicsA Single-Cell Transcriptomic Atlas of Human Lens Homeostasis and Aging
A Single-Cell Transcriptomic Atlas of Human Lens Homeostasis and Aging
PRJNA1215283 | ENA
Proteomicsprotein fragments in the aging lens
quantitative measurement of protein fragments in lens
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2019-07-01 | MSV000084028 | MassIVE
GenomicsLens epithelial cells transcriptome analysis
Lens epithelial cells transcriptome analysis
PRJNA764592 | ENA
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