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ProteomicsDehydroalanine and Dehydrobutyrine in Aging and Cataractous Lenses
Protein post-translational modifications (PTMs) have been associated with aging and age-related diseases. PTMs are particularly impactful in long-lived proteins, such as those found in the ocular lens, because they accumulate with age. Two post-translational modifications that lead to protein-protei...
ORGANISM(S): Homo sapiens (Human) 
2023-10-12 | PXD045734 | Pride
Dehydrobutyrine Aging Dehydroalanine Lens Cataracts 
UnknownSynthesis of tryptophan-dehydrobutyrine diketopiperazine and biological activity of hangtaimycin and its co-metabolites.
Not available
S-EPMC9475180 | biostudies-literature
UnknownGenetically Introducing Biochemically Reactive Amino Acids Dehydroalanine and Dehydrobutyrine in Proteins.
Not available
S-EPMC6556376 | biostudies-literature
UnknownHuman protein aging: modification and crosslinking through dehydroalanine and dehydrobutyrine intermediates.
Not available
S-EPMC4114717 | biostudies-literature
ProteomicsSynthesis and Biological Evaluation of Vioprolide B and its Dehydrobutyrine-Glycine Analogue
Herein, we describe the total synthesis of the depispeptide vioprolide B and of an analogue, in which the (E)-dehydrobutyrine amino acid was replaced by glycine. The compounds were studied in biological assays which revealed cytotoxicity solely for vioprolide B presumably by covalent binding to cyst...
ORGANISM(S): Homo sapiens (Human) 
2024-07-17 | PXD053104 | Pride
Proteomics Natural product Target id 
UnknownDehydroalanine and dehydrobutyrine in aging and cataractous lenses reveal site-specific consequences of spontaneous protein degradation.
Not available
S-EPMC11182102 | biostudies-literature
ProteomicsActivity-based profiling of Shigella virulence factor OspF in human cells
Phosphothreonine lyases are a small family of bacterial virulence factors secreted into host cells during infection by certain Gram-negative pathogens. This family of enzymes is known for its unique mechanism of silencing host immune signaling via the irreversible β-elimination of phosphothreonine (...
ORGANISM(S): Homo sapiens (Human) 
2026-02-27 | PXD073985 | Pride
Ospf Dehydrobutyrine Chemoproteomics Phosphothreonine lyase Shigella Bacterial infection Human 
UnknownTotal Synthesis of the Cyclic Depsipeptide Vioprolide D via its (Z)-Diastereoisomer.
Not available
S-EPMC7383572 | biostudies-literature
UnknownAcyl Donor Stringency and Dehydroaminoacyl Intermediates in β-Lactam Formation by a Non-ribosomal Peptide Synthetase.
Not available
S-EPMC8211430 | biostudies-literature
Unknownsyn-Elimination of glutamylated threonine in lanthipeptide biosynthesis.
Not available
S-EPMC9890492 | biostudies-literature
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