Sort   by:  
 Page size 
ProteomicsThe Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin
The bacterial secondary metabolite prodigiosin has been shown to exert anticancer, antimalarial, antibacterial and immunomodulatory properties. With regard to cancer, it has been reported to affect cancer cells but not non-malignant cells, rendering prodigiosin a promising lead compound for anticanc...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD043247 | Pride
Prodigiosin  golgi apparatus  natural compound  autophagy  target identification 
ProteomicsThermal Proteome Profiling Datasets for smarTPCA
Chemical biology and the application of small molecules has proven to be a potent perturbation strategy especially for the functional elucidation of proteins, their networks and regulators. In recent years, the cellular thermal shift assay (CETSA) and its proteome-wide extension, thermal proteome pr...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD032942 | Pride
Kinase inhibitors Small molecule arranged thermal proximity coaggregation (smartpca) Tpp with temperature range (tpp-tr) or compound concentration range (tpp-ccr) Hl-60 cell line Thermal proteome profiling (tpp) 
ProteomicsCanonical autophagy remains inactive in induced pluripotent stem cells and neuronal progenitor cells following DNA damage induced by BPDE or etoposide
(Macro-)Autophagy is a key cellular stress response mediating the recycling of long-lived or damaged proteins and organelles. In stem cells, autophagy is essential for the decision between quiescence, self-renewal and differentiation. We observed that induced pluripotent stem cells (iPSCs) and there...
ORGANISM(S): Homo sapiens (Human) 
2026-05-13 | PXD066480 | Pride
Autophagy  ipsc  npc  etoposide  bpde 
UnknownIntratumor heterogeneity and T cell exhaustion in primary CNS lymphoma.
Not available
S-EPMC9509601 | biostudies-literature
ProteomicsCo-targeting HSP90 alpha and CDK7 overcomes resistance against HSP90 inhibitors in BCR-ABL1+ leukemia cells (Vogt et al., Cell Death Dis. 2023) and Epigenetic remodeling via HDAC6 inhibition amplifies anti-tumoral immune responses in myeloid leukemia cells (Schliehe-Diecks et al., Cell Death Dis. 2026)
HSP90 inhibitors (HSP90i) have not entered routinely in the clinics, primarily due to the associated resistance via heat shock response (HSR) induction and dose limiting toxicity. In this study, we employed genetic KO and knockdown (KD) models of HSP90 isoforms (α and β) for extensive multi-omics-ba...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041871 | Pride
Knockout K562 Hsp90alpha Hsp90 Hsp90beta Proteome Lc-msms Secretome 
UnknownInvestigation of the combined effects of cannabidiol plus naltrexone on alcohol craving in alcohol dependence: study protocol of a phase II randomised, double-blind, placebo-controlled, parallel-group trial – ICONICplus Trial
Not available
S-EPMC12352239 | biostudies-literature
ProteomicsComparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.
This study represents a proteomic resource for HNSCC and SQCLC with quantitative protein expression data for 7800 proteins and provides a proteomic diagnostic signature for classification for undetermined secondary lung tumors in HNSCC patients. By quantitative mass-spectrometry-based proteomics, we...
ORGANISM(S): Homo sapiens (Human) 
2018-08-06 | PXD007705 | Pride
Head and neck cancer Human tissue proteomics Lung cancer Squamous cell carcinoma Diagnostic biomarker Metastasis 
UnknownNine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy.
Not available
S-EPMC7538230 | biostudies-literature
UnknownDeciphering colorectal cancer genetics through multi-omic analysis of 100,204 cases and 154,587 controls of European and east Asian ancestries.
Not available
S-EPMC10094749 | biostudies-literature
UnknownFine-mapping analysis including over 254,000 East Asian and European descendants identifies 136 putative colorectal cancer susceptibility genes.
Not available
S-EPMC11053150 | biostudies-literature
Sort   by:  
 Page size