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ProteomicsThe Dsc ubiquitin ligase complex identifies transmembrane degrons to degrade orphaned proteins at the Golgi
We quantified the proteome of Dsc complex mutants (tul1gld1) and ESCRT mutants (vps4). Therefore we used stable isotope labeling with amino acids in cell culture (SILAC) to identify changes in the membrane proteome of tul1gld1orvps4 cells relative to WT cells or gld1 cells (labeled with “heavy” [13C...
ORGANISM(S): Candida albicans (Yeast) 
2025-05-07 | PXD055553 | Pride
Degron Dsc complex Quality control Escrt Golgi Lipids Ubiquitin 
ProteomicsTXNIP mediates LAT1/SLC7A5 endocytosis to limit amino acid uptake in cells entering quiescence
Entry and exit from cellular quiescence require dynamic adjustments in nutrient acquisition, yet the mechanisms by which quiescent cells downregulate amino acid (AA) transport remain poorly understood. Here we show that cells entering quiescence selectively target plasma membrane-resident AA transpo...
ORGANISM(S): Homo sapiens (Human) 
2025-12-08 | PXD066527 | Pride
Nutrient transporter Hect-type ubiquitin ligase Ppxy Quiescence Arrestin Endocytosis 
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Not available
S-EPMC7884931 | biostudies-literature
UnknownAspirin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
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S-EPMC8598213 | biostudies-literature
UnknownTocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
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S-EPMC8084355 | biostudies-literature
UnknownEmpagliflozin in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
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S-EPMC10957483 | biostudies-literature
UnknownCasirivimab and imdevimab in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial.
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S-EPMC8830904 | biostudies-literature
UnknownBaricitinib in patients admitted to hospital with COVID-19 (RECOVERY): a randomised, controlled, open-label, platform trial and updated meta-analysis.
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S-EPMC9333998 | biostudies-literature
UnknownConvalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.
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S-EPMC8121538 | biostudies-literature
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Not available
S-EPMC11872607 | biostudies-literature
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