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TranscriptomicsA Model System for Studying the Transcriptomic and Physiological Changes Associated with Mammalian Host-Adaptation by Leptospira interrogans Serovar Copenhageni
Leptospirosis, an emerging zoonotic disease with worldwide distribution, is caused by spirochetes belonging to the genus Leptospira. More than 500,000 cases of severe leptospirosis are reported annually, with .10% of these being fatal. Leptospires can survive for weeks in suitably moist conditions b...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2014-03-20 | E-GEOD-53818 | biostudies-arrayexpress
ProteomicsProteomic analysis of extracellular proteins of Leptospira interrogans
Leptospira, the causative agent of leptospirosis is known to have several proteases with potential to degrade extracellular matrix. However, a multipronged approach to identify, classify, characterize and elucidate their role has not been attempted. In this study, we carried out in-depth proteomic a...
ORGANISM(S): Leptospira interrogans serovar Copenhageni str. Fiocruz L1-130 
2022-02-17 | PXD026044 | Pride
Proteomics Ls-ms/ms Leptospira interrogans 
TranscriptomicsGlobal transcriptomic response of Leptospira interrogans serovar Copenhageni upon exposure to serum
L. interrogans, a causative agent of leptospirosis, can survive in the environment for lengthy periods of time in between infection of mammalian hosts. In order to identify genes involved in survival in the early spirochetemic phase of infection, we performed a transcriptional analysis of L. interr...
ORGANISM(S): Leptospira interrogans 
2010-06-05 | E-GEOD-17942 | biostudies-arrayexpress
GenomicsLeptospira interrogans
Leptospira interrogans WGS
PRJNA1159281 | ENA
GenomicsLeptospira interrogans
Leptospira interrogans sequencing
PRJNA1377651 | ENA
GenomicsLeptospira interrogans
Leptospira interrogans sequencing
PRJNA1377652 | ENA
ProteomicsIdentification of factors involved in the adaptation to superoxide stress in pathogenic Leptospira
Pathogenic leptospires are responsible for the zoonotic disease leptospirosis. The clinical manifestations of this infection range from a febrile state to a severe life-threatening form characterized by multiple organ hemorrhages. More than one million cases of leptospirosis are currently reported a...
ORGANISM(S): Leptospira interrogans serovar Manilae 
2025-07-10 | PXD055480 | Pride
Leptospira Superoxide Oxidative stress Spirochetes Lc-ms/ms 
GenomicsLeptospira interrogans
Leptospira interrogans Raw sequence reads
PRJNA398120 | ENA
GenomicsLeptospira interrogans
Leptospira interrogans Genome sequencing
PRJNA293092 | ENA
TranscriptomicsTranscriptional response of Leptospira interrogans to iron limitation and characterization of putative Fur-like protein
Leptospirosis is a globally significant zoonotic disease caused by Leptospira spp. Iron is essential for growth of most bacterial species. Since availability of iron is low in the host, pathogens have evolved complex iron acquisition mechanisms to survive and establish infection. Virulence genes in ...
ORGANISM(S): Leptospira interrogans 
2010-05-05 | E-GEOD-20422 | biostudies-arrayexpress
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