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TranscriptomicsMammary gene expression profile of goats receiving high or low forage diets supplemented or not with lipids
Animal nutrition considerably affects milk composition that influences its nutritional quality. Milk component synthesis and secretion by the mammary gland involve the expression of a large number of genes whose nutritional regulation remains poorly defined. In this study, 16 lactating goats receive...
ORGANISM(S): Capra hircus 
2009-11-29 | E-GEOD-11592 | biostudies-arrayexpress
TranscriptomicsImpact of monomeric and oligomeric flavanols (MOF) consumption on the gene expression profile of leukocytes (human)
Background: In a recent intervention study, the daily supplementation with 200mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene exp...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54325 | biostudies-arrayexpress
TranscriptomicsDietary flavanols modulate the transcription of genes involved in cardiovascular pathology with complex changes of their DNA methylation state
Background: In a recent intervention study, the daily supplementation with 200 mg monomeric and oligomeric flavanols (MOF) from grape seeds for 8 weeks revealed a vascular health benefit in male smokers. The objective of the present study was to determine the impact of MOF consumption on the gene ex...
ORGANISM(S): Homo sapiens 
2014-07-30 | E-GEOD-54643 | biostudies-arrayexpress
TranscriptomicsImpact of CSN1S1 polymorphism on mammary transcriptome of food-deprived lactating goats
Genetic (animal species, breed and genotype) has a considerable effect on milk composition. In particular, goats present a remarkable polymorphism at the alpha-S1-casein (CSN1S1) locus which results in large differences in milk protein content and indirectly in milk fat content and its fatty acids c...
ORGANISM(S): Capra hircus 
2008-01-02 | E-GEOD-6642 | biostudies-arrayexpress
TranscriptomicsImpact of CSN1S1 polymorphism on mammary transcriptome of lactating goats
Genetic (animal species, breed and genotype) has a considerable effect on milk composition. In particular, goats present a remarkable polymorphism at the alpha-S1-casein (CSN1S1) locus which results in large differences in milk protein content and indirectly in milk fat content and its fatty acids c...
ORGANISM(S): Capra hircus 
2010-05-27 | E-GEOD-6637 | biostudies-arrayexpress
TranscriptomicsImpact of CSN1S1 polymorphism on caprine mammary transcriptome
Goat's alphaS1-casein (CSN1S1) polymorphism has a significant effect on milk protein and lipid composition, which affects the nutritional quality and technological properties of milk. Moreover, this polymorphism has a large impact on the morphology of mammary epithelial cells. To explore the metabol...
ORGANISM(S): Capra hircus 
2010-05-27 | E-GEOD-6646 | biostudies-arrayexpress
GenomicsGenome-wide genotyping data and exome sequencing of 100 European-descent and 100 African-descent Belgians used in the EGAS000010
The 100 European-descent (EUB) and 100 African-descent (AFB) Belgians studied were genotyped for a total of 4,301,332 SNPs on the Illumina HumanOmni5-Quad BeadChips. Whole-exome sequencing was carried out for the same 200 individuals with the Nextera Rapid Capture Expanded Exome kit, on the Illumina...
EGAD00010001131 | EGA
TranscriptomicsA food deprivation affects the miRNome in the lactating goat mammary gland
Nutrition affects milk composition influencing its nutritional properties. Nutrition also modifies the expression of mammary genes, whose regulation is not completely known. MicroRNAs (miRNA) are small non-coding RNA that work as important post-transcriptional gene expression regulators by targeting...
ORGANISM(S): Capra hircus 
2015-07-01 | E-GEOD-61025 | biostudies-arrayexpress
TranscriptomicsSunflower oil supplementation affects the expression of miR-20a-5p and miR-142-5p in the lactating bovine mammary gland
Background : In lactating cow, a sunflower oil supplementation modulated the milk composition and the mammary genes expression whose mechanisms of regulations are unclear. Results : This lipid supplementation provoke, in mammary gland, the down regulation of microRNA miR-20a-5p and miR-142-5p, which...
ORGANISM(S): Bos taurus 
2016-07-01 | E-GEOD-81616 | biostudies-arrayexpress
TranscriptomicsCharacterization and comparison of lactating mouse and bovine mammary gland miRNomes
Background: The mammary gland is a dynamic organ that undergoes important physiological changes during reproductive cycles. Until now, data regarding the characterisation of miRNA in the mammary gland have been scarce and mainly focused on their abnormal expression in breast cancer. Our goal was to ...
ORGANISM(S): Bos taurus 
2014-03-24 | E-GEOD-53511 | biostudies-arrayexpress
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