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MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11858 | MetaboLights
MetabolomicsIdentification of AK4 and RHOC as novel oncogenes addicted by adult T-cell leukemia
Adult T-cell leukemia (ATL) is a highly aggressive T-cell malignancy characterized by human T-cell leukemia virus type 1 (HTLV-1) infection. ATL has a very poor prognosis and lacks satisfactory treatments; therefore, it is critical to identify novel targets in ATL cells in order to develop effective...
2025-02-03 | MTBLS11844 | MetaboLights
TranscriptomicsMolecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression - WES
Retaining the mutational pattern of tumors, immortalized cell lines represent excellent tools for the molecular study of genetic aberrations. Tumors can consist of subclones which develop under selective forces driven by mutational alterations. This explains why after therapy, relapsed clones can be...
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11039 | biostudies-arrayexpress
TranscriptomicsMolecular genetics of pre-B acute lymphoblastic leukemia sister cell lines during disease progression - RNA-seq
Retaining the mutational pattern of tumors, immortalized cell lines represent excellent tools for the molecular study of genetic aberrations. Tumors can consist of subclones which develop under selective forces driven by mutational alterations. This explains why after therapy, relapsed clones can be...
ORGANISM(S): Homo sapiens 
2021-12-02 | E-MTAB-11038 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human leukemia cell lines treated with sera from Type I diabetes patients to investigate sera-induced transcriptional signatures.
Inflammation is common to many disorders and responsible for tissue and organ damage. However, the associated peripheral cytokine milieu is frequently dilute and difficult to measure, necessitating development of more sensitive and informative biomarkers for mechanistic studies, earlier diagnosis, a...
ORGANISM(S): Homo sapiens 
2010-09-16 | E-GEOD-24147 | biostudies-arrayexpress
TranscriptomicsMusashi-2 regulates normal hematopoiesis and promotes aggressive myeloid leukemia
RNA-binding proteins of the Musashi (Msi) family are expressed in stem cell compartments and in aggressive tumors, but they have not yet been widely explored in the blood. Here we demonstrate that Msi2 is the predominant form expressed in hematopoietic stem cells (HSCs), and its knockdown leads to r...
ORGANISM(S): Homo sapiens 
2010-07-11 | E-GEOD-16432 | biostudies-arrayexpress
TranscriptomicsLeukemia Cell Lines Induce Changes in Bone Marrow Stromal Cells
Bone marrow derived stromal cells (BMSCs) are a multipotent population that supports angiogenesis, wound healing, immunomodulation and plays an active role in the hematopoietic niche. On the other hand, they are also involved in the nurturing of bone marrow tumors and metastasis, showing a pro-tumor...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-45663 | biostudies-arrayexpress
TranscriptomicsCharacterization of miRNomes in acute and chronic myeloid leukemia cells
An in-depth analysis of miRNomes in 3 human myeloid leukemia cell lines was carried out to comprehensively identify miRNAs that distinguish acute and chronic myeloid leukemias and relate to myeloid cell differentiation. Characterization the miRNomes in 3 myeloid leukemia cell lines.
ORGANISM(S): Homo sapiens 
2014-07-03 | E-GEOD-48059 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of myeloid leukemia cell lines
Cell lines. The myeloid cell lines CMK, HEL, HL-60, K-562, KASUMI-1, KG-1, LAMA-84, M-07e, MONO-MAC-1, MV4-11, NB-4, OCI-AML2, OCI-AML5, SIG-M5, THP-1, and UT-7 were obtained from the DSMZ in Braunschweig, Germany (http://www.dsmz.de). The cell line ME-1 was kindly provided by Dr. Ikuya Sakai, Ehim...
ORGANISM(S): Homo sapiens 
2012-02-24 | E-GEOD-8779 | biostudies-arrayexpress
ProteomicsHuman AML cell lines LC-MS/MS - Performance of Super-SILAC based quantitative proteomics for comparison of different acute myeloid leukemia (AML) cell lines
As a direct consequence of the high diversity of the aggressive blood cancer acute myeloid leukemia (AML), proteomic samples from patients are strongly heterogeneous, rendering their accurate relative quantification challenging. In the present study, we investigated the benefits of using a super-SI...
ORGANISM(S): Homo sapiens (Human) 
2014-07-15 | PXD000441 | Pride
Human Orbitrap velos pro Lc-ms Cell lines Super-silac Aml 
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