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ProteomicsThe protein expression landscape of the heart across humans and model organisms
Here we perform a global analysis of cardiac protein expression in humans and model organisms across cardiac chambers using quantitative mass spectrometry based proteomics. We measure >6,500 proteins in each species and create a global comparison of cardiac protein expression across species. The dat...
ORGANISM(S): Danio rerio (Zebrafish) (Brachydanio rerio) Homo sapiens (Human) Mus musculus (Mouse) Sus scrofa domesticus (domestic pig) Rattus norvegicus (Rat) Equus caballus (Horse) 
2021-02-03 | PXD012636 | Pride
Lc-ms Proteomics Species Heart Proteomes Cardiac proteomics 
ProteomicsGHB analogs confer neuroprotection through specific interaction with the CaMKII hub domain
Ca2+/calmodulin-dependent protein kinase II alpha (CaMK2A) is an emerging drug target incerebral ischemia for which limited therapeutic options exist. Here we show that small-molecule analogs of the brain metabolite gamma-hydroxybutyric acid (GHB) afford neuroprotection via interaction specifically ...
ORGANISM(S): Rattus norvegicus (Rat) 
2021-07-22 | PXD019679 | Pride
Qexactive hf Brain homogenate Affinity purification Photoaffinity labeling Rat 
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