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ProteomicsUVPD of peptides modified with N-terminal UV-absorbing chromophores
Ultraviolet photodissociation (UVPD) has emerged as a powerful alternative to conventional collision-induced dissociation (CID) for peptide and protein sequencing in mass spectrometry–based proteomics. However, UVPD efficiency depends on the presence of UV-absorbing chromophores within analytes.The ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD075227 | Pride
Chromophores Lc-ms Proteomics Nhs chemistry Uvpd 
ProteomicsEvaluating the performance of photon- and electron-based fragmentation methods in Omnitrap-LCMS analysis of N-glycopeptides
To date, collision-induced dissociation and methods based on electron transfer dissociation are considered the standard approaches for the mass spectrometry analysis of N- and O-glycopeptides, respectively, allowing for identification of both peptide and glycan compositions. In recent years, alterna...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD071023 | Pride
Glycopeptides Omnitrap Ecd Uvpd Eid 
ProteomicsBiomimetic activation enables direct functionalization with native sugars
We report a metal- and protecting-group-free strategy that enables the direct anomeric functionalization of unprotected monosaccharides and oligosaccharides in their native forms via glycosyl radical-based cross-coupling with various electrophiles under mild photoirradiation conditions. This approac...
ORGANISM(S): Escherichia coli 
2024-08-10 | PXD046389 | Pride
Peptide mapping Glycosyl radical-based cross-coupling Native sugars Protecting-group-free funxtionalization 
ProteomicsStereoretentive Post-Translational Protein Editing
Chemical post-translational methods now allow convergent side-chain editing of proteins as a form of direct chemical mutagenesis without needing to resort to genetic intervention. Current approaches that allow the creation of constitutionally native side-chains via C–C formation using off-protein...
ORGANISM(S): Escherichia coli 
2023-05-10 | PXD036570 | Pride
Protein editing Psts Chemical modification Stereoretentive Lcms 
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