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TranscriptomicsDiffuse large B-cell lymphoma
Diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin's lymphoma, is clinically heterogeneous: 40% of patients respond well to current therapy and have prolonged survival, whereas the remainder succumb to the disease. We proposed that this variability in natural history refle...
ORGANISM(S): Homo sapiens 
2002-06-27 | E-GEOD-60 | biostudies-arrayexpress
ProteomicsB cell Lymphomas present Immunoglobulin Neoantigens
Immunoglobulin gene rearrangement and somatic hypermutation have the potential to create neoantigens in non-Hodgkin B cell lymphoma. However, the presentation of these putative immunoglobulin neoantigens by B cell lymphomas has not been proven. We used MHC immunoprecipitation followed by liquid chr...
ORGANISM(S): Homo sapiens (Human) 
2019-01-07 | PXD010808 | Pride
Lymphoma Neoantigens Mhc Orbitrap 
GenomicsGenetic and Functional Drivers of Diffuse Large B Cell Lymphoma
Diffuse large B cell lymphoma (DLBCL) is the most common hematologic malignancy and is characterized by a striking degree of heterogeneity. We enrolled a total of 1001 DLBCL patients and comprehensively defined the landscape of genetic mutations, copy number alterations and expression through whole-...
EGAS00001002606 | EGA
ProteomicsB-cell compartment hyperactivation in PHIV
Despite a successful antiretroviral therapy (ART), adolescents living with perinatally acquired HIV (PHIV) experience signs of B-cell hyperactivation with expansion of 'namely' atypical B-cell phenotypes, including double negative (CD27-IgD-) and termed age associated (ABCs) B-cells(T-bet+CD11c+), w...
ORGANISM(S): Homo sapiens (Human) 
2022-03-03 | PXD031908 | Pride
Exhausted t-cells Immune activation Cahiv-1 rna Late art T-bet Cd11c Proteomic profiling B-cell hyperactivation Perinatal hiv/aids 
GenomicsGenetic Heterogeneity of Diffuse Large B Cell Lymphoma

We sequenced exomes of 94 DLBCL tumors and cell lines. 34 of the tumors had paired normal tissue. Our work elucidates commonly occurring gene-coding mutations in DLBCL.

phs000573.v1.p1 | EGA
UnknownAltered B-cell receptor signaling kinetics distinguish human follicular lymphoma B cells from tumor-infiltrating nonmalignant B cells.
Not available
S-EPMC1895530 | biostudies-literature
TranscriptomicsGenetic Heterogeneity of DLBCL
Diffuse large B-cell lymphoma (DLBCL) is the most common form of lymphoma in adults. The disease exhibits a striking heterogeneity in gene expression profiles and clinical outcomes, but its genetic causes remain to be fully defined. Through whole genome and exome sequencing, we characterized the gen...
ORGANISM(S): Homo sapiens 
2013-01-23 | E-GEOD-43606 | biostudies-arrayexpress
TranscriptomicsIntegrative profiling of follicular lymphoma at diagnosis and relapse
B-cells were purified from cyropreserved tumor cell suspensions by FACS, DNA isolated, and interogated using Affymetrix 250K Nsp SNP microarrays. Aim: To track the evolution of genetic alterations during progression of follicular lymphoma. One array per tumor.
ORGANISM(S): Homo sapiens 
2015-03-02 | E-GEOD-56311 | biostudies-arrayexpress
UnknownImplications of Brexit on the effectiveness of the UK soft drinks industry levy upon CHD in England: a modelling study.
Not available
S-EPMC10260949 | biostudies-literature
GenomicscRNA-Seq Reveals Lymphoma B Cell Diversity and T Cell Immune Checkpoint Co-Expression

Follicular lymphoma (FL) is a generally incurable B-cell malignancy which has the potential to transform into highly aggressive lymphomas. Genomic studies indicate it is often a small subpopulation rather than the dominant population in the FL that gives rise to the more aggressive subtype. To re...

phs001378 | dbGaP
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