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TranscriptomicsMelanoma miRNA trafficking triggers the tumor primary niche formation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-72620 | biostudies-arrayexpress
TranscriptomicsExpression profiling of microRNAs in primary melanocytes
DICER is a central regulator of microRNA maturation. However little is known about mechanisms regulating its expression in development or disease. While profiling miRNA expression in differentiating melanocytes, two populations were observed: some upregulated at the pre-miRNA stage, and others upre...
ORGANISM(S): Homo sapiens 
2010-04-15 | E-GEOD-21249 | biostudies-arrayexpress
ProteomicsSecond-Hand Melanoma Melanosomes Regulate Diversity Among Tumor-Associated Macrophages
Extracellular vesicles (EVs) are a key form of cell-to-cell communication. Here we reveal a new mode of communication involving the large EVs, melanosomes. Unlike small EVsexosomes, which are dissolved in the receiver cell, melanosomes stay intact within them, gain a unique protein signature, and ca...
ORGANISM(S): Homo sapiens (Human) 
2023-12-31 | PXD046421 | Pride
Melanosomes Macrophages Small ev 
ProteomicsSkin Exposure to UVB Light induces a Skin-Brain-Gonad Axis and Sexual Behavior
Ultraviolet (UV) light affects endocrinological and behavioral aspects of human sexuality via an unknown mechanism. Using a unique male-female comparative approach, we discovered that the sexual behavioral and hormonal features enhanced by UVB are mediated by the skin. In mice, UV exposure increases...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-17 | PXD025973 | Pride
Proteomics Uvb light Sexual behavior 
ProteomicsSolar exposed skin induces sex-dependent food-seeking behavior
Considering the distinct physiologies of men and women, it stands to reason that they would react differently to solar exposure, but such a study was never conducted before. Here we show that solar exposure induces food-seeking behavior, food intake and weight gain in males, but not in females, by ...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033203 | Pride
Food-seeking Solar exposure Serum 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 2
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD035648 | Pride
Metabolism Cancer Exercise 
ProteomicsExercise forms a metabolic-shield in distant organs blocking cancer progression and metastatic dissemination-Part 1
Exercise prevents cancer incidence and recurrence, yet the underlying mechanism remains mostly unknown. Here we report that exercise induces a metabolic reprogramming of internal organs, increasing their nutrient demand, thus protecting them against metastatic colonization by limiting nutrient avail...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD035630 | Pride
Metabolism Cancer Exercise 
TranscriptomicsExpression profiling of fibroblasts treated with melanosomes
mRNA profiling was performed on primary fibroblasts treated with melanosomes and untreated fibroblasts as control. The aim of this study was to explore whether melanoma-derived mature melanosomes functionally affect primary fibroblasts. A functional gene set enrichment analysis based on the resultin...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-72229 | biostudies-arrayexpress
TranscriptomicsAnalysis of melanosomal miRNAs
miRNA microarray profiling was performed for MNT-1 cells, pre-mature and mature melanosomes extracted from MNT-1 cells. In order to reveal the miRNAs that are most abundant in mature melanosomes, the most highly expressed miRNAs from mature melanosomes were compared with expression levels in pre-mat...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-72337 | biostudies-arrayexpress
TranscriptomicsAnalysis of melanosomal, exosomal and cellular miRNAs of melanoma cells
miRNA microarray profiling was performed for exosomes and secreted melanosomes of MNT-1 cells as well as WM3682 and WM3314 cells and melanosomes isolated from cell homogenates. The aim of this study is to compare the miRNA content of exosomes and secreted melanosomes and to assess differences in the...
ORGANISM(S): Homo sapiens 
2016-08-09 | E-GEOD-79411 | biostudies-arrayexpress
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