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UnknownSequential deletion of CD63 identifies topologically distinct scaffolds for surface engineering of exosomes in living human cells.
Not available
S-EPMC7313400 | biostudies-literature
TranscriptomicsThe SWI/SNF protein ATRX co-regulates pseudoautosomal genes that have translocated to autosomes in the mouse genome
Pseudoautosomal regions (PAR1 and PAR2) in eutherians retain homologous regions between the X and Y chromosomes that play a critical role in the obligatory X-Y crossover during male meiosis. Genes that reside in the PAR1 are exceptional in that they are rich in repetitive sequences and undergo a ve...
ORGANISM(S): Mus musculus 
2009-08-01 | E-GEOD-12454 | biostudies-arrayexpress
UnknownRNA-Seq Analysis Reveals CCR5 as a Key Target for CRISPR Gene Editing to Regulate In Vivo NK Cell Trafficking.
Not available
S-EPMC7922167 | biostudies-literature
TranscriptomicsInhibition of proliferation and induction of autophagy by atorvastatin in PC3 prostate cancer cells correlate with downregulation of Bcl2 and upregulation of miR-182 and p21 [Gene expression]
The epidemiologic association between statin use and decreased risk of advanced prostate cancer suggests that statins may inhibit prostate cancer development and/or progression. Studies were performed to determine the effects of a model statin, atorvastatin (ATO), on the proliferation and different...
ORGANISM(S): Homo sapiens 
2013-09-30 | E-GEOD-46374 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Cyp26b1-/-skin and En1cre;Cyp26b1f/- epidermal and dermal Transcriptomes
Purpose: Next-generation sequencing (NGS) has revolutionized systems-based analysis of cellular pathways. The goals of this study are to compare NGS-derived skin transcriptome profiling (RNA-seq) to determine pathways and networks dependent on retinoic acid during skin development. Methods: Skin mRN...
ORGANISM(S): Mus musculus 
2012-12-07 | E-GEOD-40436 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of bone marrow derived mast cells from WASP negative and wild type mice to investigate the role of WASP in Kit signalling
The pleiotropic RTK Kit can provide cytoskeletal signals that define cell shape, positioning and migration, but the underlying mechanisms are less well understood. Here we provide evidence that Kit signals through WASP (Wiskott-Aldrich Syndrome Protein), the central hematopoietic actin nucleation- ...
ORGANISM(S): Mus musculus 
2009-08-29 | E-MEXP-2282 | biostudies-arrayexpress
TranscriptomicsA single recurrent dominant variant in ITPR3 leads to a syndromic immunodeficiency
Intracellular calcium levels are finely tuned through intricate actions of a number of channels and transporters, including those at key endocellular stores, e.g. endoplasmic reticulum (ER), lysosomes, and mitochondria. Along with the highly homologous genes Inositol 1,4,5-trisphosphate (IP3) recept...
ORGANISM(S): Homo sapiens 
2023-07-05 | E-MTAB-13124 | biostudies-arrayexpress
TranscriptomicsTissue-specific patterns of gene expression in the epithelium and stroma of normal colon in healthy individuals in an aspirin intervention trial
The objectives of this study were to measure effects of an aspirin intervention on gene expression in normal colonic epithelial and stromal tissue in healthy humans and to determine whether response differed by UGT1A6*2 genotype. We also sought to characterize gene expression differences within colo...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-71571 | biostudies-arrayexpress
UnknownGenome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
Not available
S-EPMC3622441 | biostudies-literature
TranscriptomicsDifferential Roles of ERM-NM-1 and ERM-NM-2 in Normal and Neoplastic Development in the Mouse Mammary Gland
The present experiments were performed to determine the roles of estrogen receptors M-NM-1 and M-NM-2 (ERM-NM-1 and ERM-NM-2) in normal and neoplastic development in the mouse mammary gland. In wild-type mice, in vivo administration of estradiol (E) + progesterone (P) stimulated mammary ductal growt...
ORGANISM(S): Mus musculus 
2014-10-18 | E-GEOD-62451 | biostudies-arrayexpress
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