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MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsProton irradiation augments the reduction in tumor progression observed with advanced age
Proton irradiation is touted for its improved tumor targeting due to the physical advantages of ion beams for radiotherapy. Recent studies from our laboratory have shown that, in addition to targeting advantages, proton irradiation can inhibit angiogenic and immune factors and thereby modulate tumor...
ORGANISM(S): Mus musculus 
2014-01-01 | E-GEOD-45609 | biostudies-arrayexpress
TranscriptomicsEffector T cells driving monophasic vs relapse/remitting experimental autoimmune uveitis show unique pathway signatures
Experimental autoimmune uveitis (EAU) in Lewis rats is a model for the clinical heterogeneity of human uveitis. The autoantigens inducing disease in the rat are also seen in human disease. Depending upon the specific autoantigen used, the experimental disease course can be either monophasic or relap...
ORGANISM(S): Rattus norvegicus 
2010-12-01 | E-GEOD-19652 | biostudies-arrayexpress
TranscriptomicsAge and Space Irradiation Modulate Tumor Progression: Implications for Carcinogenesis Risk
Age plays a major role in tumor incidence and is an important consideration when modeling the carcinogenesis process or estimating cancer risks. Epidemiological data show that from adolescence through middle age, cancer incidence increases with age. This effect is commonly attributed to a lifetime a...
ORGANISM(S): Mus musculus 
2013-06-13 | E-GEOD-45606 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human hGRbeta in the absence of hGR alpha
The human glucocorticoid receptor (GR) is expressed as two alternately spliced Cterminal isoforms: α and β. In contrast to the canonical hGRα, hGRβ is constitutively nuclear, is not thought to bind ligand, and is believed to affect gene transcription only by acting as a dominant negative to hGRÎ...
ORGANISM(S): Homo sapiens 
2008-06-13 | E-GEOD-5310 | biostudies-arrayexpress
TranscriptomicsDichlorvos exposure results in large scale disruption of energy metabolism in the liver of the zebrafish, Danio rerio
Background: Exposure to dichlorvos (DDVP), an organophosphorus pesticide, is known to result in neurotoxicity as well as other metabolic perturbations. However, the molecular causes of DDVP toxicity are poorly understood, especially in cells other than neurons and muscle cells. To obtain a better un...
ORGANISM(S): Danio rerio 
2015-11-05 | E-GEOD-66257 | biostudies-arrayexpress
TranscriptomicsBone signaling in rat middle ear and cochlea by transcription profiling
* Bone signaling in middle ear development *
Common middle ear diseases, such as chronic suppurative otitis media and cholesteatoma, may affect bone behavior in the middle ear air cell system.
This study analyzed gene expression of bone-related signaling factors and gene sets from lini...
ORGANISM(S): Rattus norvegicus 
2014-02-20 | E-MTAB-2336 | biostudies-arrayexpress
TranscriptomicsWhole blood gene expression profiles distinguish clinical phenotypes of venous thromboembolism [Set1]
Recurrent venous thromboembolism (VTE) occurs infrequently following a provoked event but occurs in up to 30% of individuals following an initial unprovoked event. We studied 134 patients with VTE separated into 3 groups: (1) ‘low-risk’ patients had ≥1 provoked VTE; (2) ‘moderate-risk’ pa...
ORGANISM(S): Homo sapiens 
2015-11-23 | E-GEOD-48000 | biostudies-arrayexpress
TranscriptomicsWhole Adult Organism Transcriptional Profiling of Metal Exposures in Zebrafish
A convergence of technological breakthroughs in the past decade has facilitated the development of rapid screening tools for biomarkers of toxicant exposure and effect. Platforms using the whole adult organism to evaluate the genome-wide response to toxicants are especially attractive. Recent work d...
ORGANISM(S): Danio rerio 
2014-06-10 | E-GEOD-50648 | biostudies-arrayexpress
GenomicsMus musculus
Proton irradiation augments the reduction in tumor progression observed with advanced age
PRJNA195396 | ENA
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