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MetabolomicsFecal microbiota transplantation plus anti-PD-1 immunotherapy in advanced melanoma: a phase I trial

Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

2025-02-27 | MTBLS711 | MetaboLights
TranscriptomicsCharacterization of four TCE-dechlorinating microbial enrichments grown with different cobalamin stress and methanogenic conditions
Four stable and robust TCE-dechlorinating microbial communities were enriched from TCE-contaminated groundwater under four different conditions exploring two parameters, high and low methanogenic activity (Meth and NoMeth), with and without vitamin B12 supplement (MethB12 and NoMethB12, Meth and No...
ORGANISM(S): environmental samples 
2013-06-30 | E-GEOD-33530 | biostudies-arrayexpress
ProteomicsA pipeline that integrates the discovery and verification of plasma protein biomarkers reveals candidate markers for cardiovascular disease
Addona TA, Shi X, Keshishian H, Mani DR, Burgess M, Gillette MA, Clauser KR, Shen D, Lewis GD, Farrell LA, Fifer MA, Sabatine MS, Gerszten RE, Carr SA. Nat Biotechnol. 2011, 29(7):635-43. doi: 10.1038/nbt.1899. PMCID:PMC3366591. Discovery, AIMS, and MRM datasets Discovery_Tranche_hash: b/quYtp/Q8fY...
2013-12-19 | MSV000078513 | MassIVE
TranscriptomicsTranscription profiling of different types of cells in murine hair follicle to study cell type-specific gene expression.
Hair follicle matrix, outer root sheath, dermal papilla cells and melanocytes and a dermal fraction enriched in fibroblasts were FACS isolated from 4d backskins. Targets from two biological replicates of each were generated and the expression profiles were determined using Affymetrix Mouse Genechip...
ORGANISM(S): Mus musculus 
2007-09-07 | E-GEOD-3142 | biostudies-arrayexpress
TranscriptomicsSingle cell RNAseq of immune and stromal cells in murine lung cancer
Immune responses against tumor cells depend on T lymphocyte attraction and activity within the tumor microenvironment. Specialized immune-interacting fibroblasts, commonly referred to as fibroblastic reticular cells (FRC), form specialized niches in secondary lymphoid organs, originate from embryoni...
ORGANISM(S): Mus musculus 
2024-11-19 | E-MTAB-13708 | biostudies-arrayexpress
TranscriptomicsRNA-seq of Zbtb20-expressing Tregs against activated (CD62Llo) and naive (CD62Lhi) Tregs that do not express Zbtb20
The objective of this study was to determine if a subset of regulatory T cells (Tregs) expressing the transcription factor, Zbtb20, played a unique role in the function of the immune system. Genetic reporter mice were used to isolate Zbtb20-expressing Tregs as well as activated (CD62Llo) and naive (...
ORGANISM(S): Mus musculus 
2022-02-25 | E-MTAB-11442 | biostudies-arrayexpress
TranscriptomicsComparative Genomics of D. ethenogenes 195 and an Unsequenced Dehalococcoides-Containing Enrichment Culture
Tetrachloroethene (PCE) and trichloroethene (TCE) are prevalent groundwater contaminants that can be completely reductively dehalogenated by Dehalococcoides organisms. A Dehalococcoides-containing microbial consortium (ANAS) with the ability to degrade TCE to ethene, an innocuous end-product, was pr...
ORGANISM(S): Dehalobacter restrictus 
2010-06-20 | E-GEOD-9612 | biostudies-arrayexpress
UnknownRelationship between obesity and the risk of clinically significant depression: Mendelian randomisation study.
Not available
S-EPMC4076654 | biostudies-literature
TranscriptomicsPatterns of gene expression associated with recovery and injury in heat-stressed rats
Background: The in vivo gene response associated with hyperthermia and subsequent return to homeostasis or development of heat illness is poorly understood. Early activation of gene networks in the heat stress response is likely to lead to the systemic inflammation, multi-organ functional impairment...
ORGANISM(S): Rattus norvegicus 
2015-01-14 | E-GEOD-56740 | biostudies-arrayexpress
UnknownAre myocardial infarction--associated single-nucleotide polymorphisms associated with ischemic stroke?
Not available
S-EPMC3622211 | biostudies-literature
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