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ProteomicsArsenic induces reversible nitrosative stress and behavioural changes in mice
Studies on exposure of mice to Arsenic, combined with unique tools developed in our laboratory to determine the consequences of NO formation in mouse brain and neuronal cell culture, will probe mechanistic pathways of nitrosative damage operable in behavioural development.
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD012691 | Pride
Nitric oxide Brain Autism. s-nitrosylation Snotrap Arsenic 
UnknownRapid-dissolving electrospun nanofibers for intra-vaginal antibiotic or probiotic delivery.
Not available
S-EPMC10530173 | biostudies-literature
MetabolomicsDirect on-swab metabolic profiling of vaginal microbiome:host interactions during pregnancy and preterm birth

The pregnancy vaginal microbiome contributes to risk of preterm birth, the primary cause of death in children under 5 years of age. Here we describe direct on-swab metabolic profiling by Desorption Electrospray Ionization Mass Spectrometry (DESI-MS) for sample preparation-free characterisation of...

2021-09-23 | MTBLS717 | MetaboLights
TranscriptomicsRNA-Seq of synovial tissue biopsies from individuals with rheumatoid arthritis from the R4RA randomised clinical trial
Transcriptomic profiles of synovial biopsies of rheumatoid arthritis (RA) patients who were recruited into the R4RA randomised clinical trial. Patients were randomised to treatment with rituximab or tocilizumab. All patients fulfilled the 2010 ACR/EULAR classification criteria for RA and were eligib...
ORGANISM(S): Homo sapiens 
2022-04-26 | E-MTAB-11611 | biostudies-arrayexpress
UnknownCombined BRAF (Dabrafenib) and MEK inhibition (Trametinib) in patients with BRAFV600-mutant melanoma experiencing progression with single-agent BRAF inhibitor.
Not available
S-EPMC4226803 | biostudies-literature
UnknownPhase II study of the MEK1/MEK2 inhibitor Trametinib in patients with metastatic BRAF-mutant cutaneous melanoma previously treated with or without a BRAF inhibitor.
Not available
S-EPMC4878037 | biostudies-literature
MetabolomicsBotanical collections as an opportunity to explore nature through the time: An untargeted metabolomic study in historical and modern Nicotiana leaves

The living and dried specimens in botanical collections play an important role in society for scientific and recreational purposes, offering the opportunity to obtain both macroscopic and molecular information for individual plants, ecosystems, and environmental studies. Untargeted metabolomics i...

2024-03-06 | MTBLS4564 | MetaboLights
ProteomicsHypoxia shapes the immune landscape in lung injury and promotes the persistence of inflammation
Hypoxemia is a defining feature of acute respiratory distress syndrome (ARDS), an often-fatal complication of pulmonary or systemic inflammation, yet the resulting tissue hypoxia, and its impact on immune responses, is often neglected. Here we showed that ARDS patients were hypoxaemic and monocytope...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-08-12 | PXD033151 | Pride
Ards Dia Classical monocytes Hypoxia 
MetabolomicsMetabolomics Identifies Metabolic Markers of Maturation in Human Pluripotent Stem Cell-Derived Cardiomyocytes
Cardiovascular disease is a leading cause of death worldwide. Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) hold immense clinical potential and recent studies have enabled generation of virtually pure hPSC-CMs with high efficiency in chemically defined and xeno-free conditions. Despi...
2018-04-24 | MTBLS425 | MetaboLights
UnknownSafety and efficacy of nivolumab in combination with sunitinib or pazopanib in advanced or metastatic renal cell carcinoma: the CheckMate 016 study.
Not available
S-EPMC6196426 | biostudies-literature
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