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TranscriptomicsTranscription profiling of human CMV-stimulated CD69+, hCMV-stimulated CD69- and unstimulated monoclonal CD4+ T-LGL lymphocytes from peripheral blood samples from four TCRVbeta+/CD4+ T-LGL lymphocytosis patients
Recent studies suggest the potential involvement of common antigenic stimuli on the ontogeny of monoclonal TCRalphabeta+/CD4+/NKa+/CD8-/+dim T-large granular lymphocyte (LGL) lymphocytosis. Since healthy individuals show (oligo)clonal expansions of hCMV-specific TCRVbeta+/CD4+/cytotoxic/memory T-cel...
ORGANISM(S): Homo sapiens 
2008-10-25 | E-GEOD-12488 | biostudies-arrayexpress
ProteomicsLgl protein interactome - Lgl reduces endosomal vesicle acidification and Notch signaling by promoting the interaction between Vap33 and the V-ATPase complex
To identify Lgl binding proteins, we purified Lgl-containing protein complexes from cultured Drosophila S2 cells, using the single-step streptavidin purification from stable cell lines expressing SBP-tagged Lgl, followed by nanoLC-MS/MS analysis of the interactors. This study revealed the binding of...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2018-06-10 | PXD009568 | Pride
Lgl S2 cells Drosophila 
TranscriptomicsTransgenic NUP98-HOXA9 Zebrafish Embryos: Unactivated ('lGl') vs. Cre-activated ('NHA9')
Transcriptional profiling of zebrafish embryos at 28 hours post fertilization, comparing control 'unactivated' Tg(spi1::lox-eGFP-lox::NHA9) embryos with experimental 'Cre-activated' Tg(spi1::NHA9) embryos. Goal was to determine the effects of expressing NUP98-HOXA9 oncogene on global and blood cell-...
ORGANISM(S): Danio rerio 
2014-10-30 | E-GEOD-62793 | biostudies-arrayexpress
GenomicA Phase 2 Study of Tipifarnib in Large Granular Lymphocyte (LGL) Leukemia

LGL leukemia can be divided into three subsets including the following: αβ or γδT-LGL and NK-LGL leukemia. All three subtypes will be enrolled using a two-stage design. The primary endpoint of the study is assessment of overall clinical response. Correlative laboratory studies...

phs000594 | dbGaP
TranscriptomicsRajala_et_al_2013
Large lymphocytic leukemia (LGL) is a chronic clonal lymphoproliferative disorder, characterized by expansion of cytotoxic CD8+ T-cells or NK-cells. We compared gene expression of 3 LGL leukemia patients with STAT3 mutation (Patients 1, 2, and 3), 3 LGL leukemia patients with STAT5b mutation (Patien...
ORGANISM(S): Homo sapiens 
2013-04-15 | E-MTAB-1611 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood mononuclear cells isolated from LGL leukemia samples reveals role of sphingolipid signaling of cytotoxic lymphocytes
We used microarrays to expression profile peripheral blood mononuclear cells (PBMCs) from LGL leukemia patients and control subjects to identify survival pathways that render leukemic LGL resistant to activation induced cell death. Experiment Overall Design: Leukemic PBMC RNA from 30 patients was ex...
ORGANISM(S): Homo sapiens 
2008-06-11 | E-GEOD-10631 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of neoplastically transformed and wild type wing imaginal discs of Drosophila
In Drosophila, homozygosity for tumor suppressors, like lethal giant larvae, lgl, results in neoplastic transformation of imaginal disc epithelium - characterized by loss of their apico-basal polarity, unrestricted growth and invasion into neighboring tissues/organs. In genetic mosaics, however, lgl...
ORGANISM(S): Drosophila melanogaster 
2011-06-08 | E-MEXP-2753 | biostudies-arrayexpress
UnknownGenomics of LGL leukemia and select other rare leukemia/lymphomas.
Not available
S-EPMC6779335 | biostudies-literature
TranscriptomicsExpression profiles from Drosophila melanogaster scrib and lgl mutant wing imaginal disc and brain complexes at day 9 after egg deposition (AED) versus wild type at day 5 AED
mRNA microarray of Drosophila wing imaginal discs or brain complexes from lgl27S3/lglE2S31 (lgl-null), scrib1/scrib2 or wild-type 3rd instar larvae RNA was isolated from 20 pairs of wing discs/brain complexes per sample (i.e 20 individuals). Samples were from 5 day AED wildtype and 9 day AED mutant ...
ORGANISM(S): Drosophila melanogaster 
2014-01-31 | E-GEOD-48852 | biostudies-arrayexpress
UnknownHow I treat LGL leukemia.
Not available
S-EPMC3062292 | biostudies-literature
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