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ProteomicsLGP2 binds PACT to regulate RIG-I- and MDA5-mediated antiviral response
The RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) trigger inflammatory and antiviral responses by sensing non-self RNA molecules produced during viral replication. LGP2 regulation of RIG-I and MDA5-dependant type-I interferon signaling is a matter of controversy. Here we show that LGP2 interacts...
ORGANISM(S): Homo sapiens (Human) Mengo virus 
2019-10-02 | PXD013191 | Pride
Rig-1 Virus Rna silencing machinery Pact Lgp2 
GenomicsmRNA expression profile in LGP2 and LGP2-4KR transgenic (Tg) HEK293 cells stimulated with short poly I:C
mRNA expression profile in LGP2 and LGP2-4KR transgenic (Tg) HEK293 cells stimulated with short poly I:C
PRJNA736018 | ENA
GenomicsEffect of LGP2 in the development of glioma [ChIP-seq]
Effect of LGP2 in the development of glioma [ChIP-seq]
PRJNA1164278 | ENA
GenomicsEffect of LGP2 in the development of glioma [RNA-seq]
Effect of LGP2 in the development of glioma [RNA-seq]
PRJNA1164269 | ENA
TranscriptomicsmRNA expression profile in LGP2 and LGP2-4KR transgenic (Tg) HEK293 cells stimulated with short poly I:C
mRNA expression profiles were compared between wild-type LGP2 and four amino acid replacement LGP2 (LGP2-4KR) cells in the presence or absence of a RIG-I ligand, short poly I:C.
ORGANISM(S): Homo sapiens 
2022-06-07 | GSE176363 | GEO
GenomicsLGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs.
LGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs.
PRJNA449826 | ENA
ProteomicsThe RIG-I like receptor LGP2 inhibits Dicer-dependent processing of long double-stranded RNA and blocks RNA interference in mammalian cells.
In vertebrates, the presence of viral RNA in the cytosol is sensed by members of the RIG-I like receptor (RLR) family , which signal to induce production of type I interferons (IFN). These key anti-viral cytokines act in a paracrine and autocrine manner to induce hundreds of interferon-stimulated ge...
ORGANISM(S): Homo sapiens (Human) 
2018-01-17 | PXD008364 | Pride
Immunobiology Viral infection Human 
TranscriptomicsEffect of LGP2 in the development of glioma [RNA-seq]
To investigate the function LGP2 in the regulation of tumor progression and development, we established 2 T98G cell lines in which LGP2 gene has been overexpressed.
ORGANISM(S): Homo sapiens 
2025-01-01 | GSE277822 | GEO
GenomicsEffect of LGP2 in the development of glioma [ChIP-seq]
To investigate the function LGP2 in the regulation of tumor progression and development, we established 2 T98G cell lines in which LGP2 gene has been overexpressed.
ORGANISM(S): Homo sapiens 
2025-01-01 | GSE277823 | GEO
TranscriptomicsLGP2 virus sensor regulates gene expression network mediated by TRBP-bound microRNAs.
To reveal the fuction of cytoplasmic virus sensor protein, LGP2, on RNA silencing, we analyzed gene expression profiles on HeLa WT and LGP2 knockout cells, which were generated with CRISPR/Cas system.
ORGANISM(S): Homo sapiens 
2018-06-29 | GSE113028 | GEO
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