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ProteomicsLGP2 binds PACT to regulate RIG-I- and MDA5-mediated antiviral response
The RIG-I-like receptors (RLRs: RIG-I, MDA5 and LGP2) trigger inflammatory and antiviral responses by sensing non-self RNA molecules produced during viral replication. LGP2 regulation of RIG-I and MDA5-dependant type-I interferon signaling is a matter of controversy. Here we show that LGP2 interacts...
ORGANISM(S): Homo sapiens (Human) Mengo virus 
2019-10-02 | PXD013191 | Pride
Rig-1 Virus Rna silencing machinery Pact Lgp2 
GenomicsEffect of PACT knockout on LNCaP protate cancer cells
Effect of PACT knockout on LNCaP protate cancer cells
PRJNA1064892 | ENA
GenomicsPACT-mediated regulation of endogenous dsRNA sensing by PKR
PACT-mediated regulation of endogenous dsRNA sensing by PKR
PRJNA1123226 | ENA
ProteomicsPeste des petits ruminants virus nucleocapsid protein interacts with PACT and induces stress granule to promote viral replication
Stress granules (SGs) formation is a conserved cellular strategy to reduce stress-related damage regulating cell survival. A Mass spectrometry-based profiling of the interactome of PPRV N protein revealed that PPRV N interacted with PACT to regulate the assembly of SGs. N protein inhibited the inter...
ORGANISM(S): Homo Sapiens 
2022-12-27 | PXD039104 |
TranscriptomicsEffect of PACT knockout on LNCaP protate cancer cells
PACT, encoded by the PRKRA gene, is a double-stranded RNA binding protein which has two main mechanisms of action; functioning as an activator of both protein kinase RNA (PKR) and retinoic acid-inducible gene 1 (RIG-1) to facilitate innate antiviral defense mechanisms in mammals; and PACT is also an...
ORGANISM(S): Homo sapiens 
2025-12-02 | GSE253245 | GEO
GenomicsChildhood Asthma Research and Education (CARE) Network Trial - Pediatric Asthma Controller Trial (PACT)(CARE-PACT-BioLINCC)
Childhood Asthma Research and Education (CARE) Network Trial - Pediatric Asthma Controller Trial (PACT)(CARE-PACT-BioLINCC)
PRJNA1520285 | ENA
GenomicsChildhood Asthma Research and Education (CARE) Network Trial - Pediatric Asthma Controller Trial (PACT)(CARE-PACT-BioLINCC)
Childhood Asthma Research and Education (CARE) Network Trial - Pediatric Asthma Controller Trial (PACT)(CARE-PACT-BioLINCC)
PRJNA1520286 | ENA
OtherPACT-mediated regulation of endogenous dsRNA sensing by PKR
Protein kinase R (PKR), an innate immune sensor for double-stranded RNA (dsRNA), is critical for antiviral defense, but its aberrant activation by cellular dsRNA is linked to various diseases. The dsRNA-binding protein PACT plays a crucial and controversial role in the PKR pathway. We demonstrate th...
ORGANISM(S): Homo sapiens 
2024-06-16 | GSE269684 | GEO
TranscriptomicsPACT suppresses PKR activation through dsRNA binding and dimerization, and is a therapeutic target for triple-negative breast cancer
Triple-negative breast cancer (TNBC), the deadliest breast cancer subtype, lacks broadly applicable targeted therapies. Induction of ‘viral mimicry’ through activation of viral double-stranded RNA (dsRNA) sensors has potential therapeutic applications for TNBC and other cancers. Suppressors of dsRNA...
ORGANISM(S): Homo sapiens 
2025-06-03 | GSE298233 | GEO
OtherLong non-coding RNA DARS-AS1 promotes tumor progression by suppressing PACT-mediated PKR activation
Cancer cells evolve various mechanisms to overcome cellular stresses and maintain progression. Protein kinase R (PKR) and its protein activator (PACT) are the initial responders in monitoring diverse stress signals and lead to cell proliferation inhibition and cell apoptosis in consequence. However,...
ORGANISM(S): Homo sapiens 
2022-05-15 | GSE197980 | GEO
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