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ProteomicsThe role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency
Testosterone is essential to maintain qualitative spermatogenesis. Nonetheless, no studies have been yet performed in humans to analyze the testosterone-mediated expression of the sperm proteins and their importance in reproduction. Thus, this study aimed to identify sperm protein alterations in mal...
ORGANISM(S): Homo sapiens (Human) 
2022-05-09 | PXD032270 | Pride
Proteomics Hypogonadism Tmt Lh deficiency Male infertility Sperm Testosterone 
TranscriptomicsTranscriptional effect of the luteinizing hormone surge in bovine granulosa cells during the peri-ovulation period
Granulosa cells from three different stages were used to assess the short- and long-term effects of luteinizing hormone (LH) on follicle differentiation: 1) 2 h before induction of the LH surge, 2) 6 h and 3) 22 h after the LH surge. Three time points experiment: 2h pre-LH, 6h post-LH and 22h post-L...
ORGANISM(S): Bos taurus 
2015-05-27 | E-GEOD-69247 | biostudies-arrayexpress
UnknownReduced FSH and LH action: implications for medically assisted reproduction.
Not available
S-EPMC8129594 | biostudies-literature
TranscriptomicsTranscription profiling of rat and mouse granulosa cells infected with adenoviral vectors expressing two FOXO1 mutants reveals FSH and FOXO1 regulate genes in the sterol/steroid and lipid biosynthetic pathways in granulosa cells
The forkhead box transcription factor FOXO1 is highly expressed in granulosa cells of growing follicles but is down-regulated by FSH in culture or by LH-induced luteinization in vivo. To analyze the function of FOXO1, we infected rat and mouse granulosa cells with adenoviral vectors expressing two F...
ORGANISM(S): Rattus norvegicus 
2009-04-25 | E-GEOD-15727 | biostudies-arrayexpress
UnknownChromatin transitions triggered by LH density as epigenetic regulators of the genome.
Not available
S-EPMC9561278 | biostudies-literature
UnknownNovel roles of luteinizing hormone (LH) in tissue regeneration-associated functions in endometrial stem cells.
Not available
S-EPMC9279474 | biostudies-literature
ProteomicsmiR-29a/b1 regulates the pituitary gland luteinizing hormone secretion and affects mouse ovulation
miR-29a/b1 was reported to be involved in the regulation of reproductive function in female mice, but the underlying molecular mechanisms were not clear. In this study, female mice lacking miR-29a/b1 showed a delay in vaginal opening, irregular estrus cycles, ovulation disorder and infertility. Howe...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD017106 | Pride
Reproduction Knockout Mir-29a/b1 Lh Ovulation 
TranscriptomicsGene expression profiles of Liuwei Dihuang Pill treatment postmenopausal osteoporosis with kidney Yin deficiency
Investigate gene expression profiles of Liuwei Dihuang Pill treatment postmenopausal osteoporosis with kidney Yin deficiency in peripheral blood Liuwei Dihuang Pill (LDP), a classic Chinese medicinal formula, has been used to treat PMO with kidney YIN deficiency for three months. Whole human genome ...
ORGANISM(S): Homo sapiens 
2014-05-06 | E-GEOD-57273 | biostudies-arrayexpress
TranscriptomicsGene expression in the liver and colon of mice fed diets HH, LL, HL and LH
Transcriptional profiling of mice fed a diet deficient in selenium and folate during weaning and in utero (LL), a diet deficient in selenium and folate during weaning but not in utero (HL), a diet sufficient in selenium and folate during weaning but deficient in utero (LH), and a diet sufficient in ...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-68179 | biostudies-arrayexpress
TranscriptomicsObox1 deficiency induceds subfertility in female mice
Obox1 was considered to be a maternal factor participates in oogenesis and follicle development, but its function remains largely undefined. In this study, we demonstrated that Obox1-null female mice displayed subfertility as evidenced by decreased litter size. Obox1 deficiency resulted in less oocy...
ORGANISM(S): Mus musculus 
2025-07-02 | GSE207448 | GEO
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