Fecal microbiota transplantation (FMT) represents a potential strategy to overcome resistance to immune checkpoint inhibitors in patients with refractory melanoma; however, the role of FMT in first-line treatment settings has not been evaluated. We conducted a multicenter phase I trial combining ...

The marine microbiome contributes to nearly half of our planet’s net primary production. It plays a central role in the ocean’s carbon cycle through both passive and active release of metabolites into seawater, forming a pool of dissolved compounds known as the marine exometabolome.