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GenomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (ChIP-Seq)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Mus musculus 
2015-04-23 | E-GEOD-60223 | biostudies-arrayexpress
GenomicsWomen's Health Initiative Clinical Trial and Observational Study

The Women's Health Initiative (WHI) is a long-term national health study that has focused on strategies for preventing heart disease, breast and colorectal cancer, and osteoporotic fractures in postmenopausal women. The original WHI study included 161,808 postmenopausal women enrolled between...

phs000200.v7.p2 | EGA
UnknownLanthanide and asymmetric catalyzed syntheses of sterically hindered 4-isoxazolyl-1,4-dihydropyridines and 4-isoxazolyl-quinolones.
Not available
S-EPMC4714355 | biostudies-literature
TranscriptomicsTelomerase subunit TERT regulates MYC stability independent of its role on telomeres (array)
Constitutively active MYC and reactivated telomerase often co-exist in cancers. While the reactivation of telomerase is thought to be essential for replicative immortality, MYC, in conjunction with co-factors, confers several growth advantages to cancer cells. However, it is unclear which co-factors...
ORGANISM(S): Homo sapiens 
2015-04-23 | E-GEOD-60175 | biostudies-arrayexpress
MetabolomicsIdentifying metabolic alterations associated with coral growth anomalies using 1H NMR metabolomics
Coral growth anomalies (GAs) are tumor-like protrusions that are detrimental to coral health, impacting both the coral skeleton and soft tissues. These lesions are increasingly found throughout the tropics and are commonly associated with high human population density, yet little is known about the ...
2021-06-15 | MTBLS2424 | MetaboLights
TranscriptomicsPDK1 Signaling Towards PLK1-Myc Activation Confers Oncogenic Transformation and Tumor Initiating Cell Activation and Resistance to mTOR-targeted Therapy.
Although 3-Phosphoinositide-dependent protein kinase-1 (PDK1) has been predominately linked to PI3K-AKT pathway, it may also evoke additional signaling outputs to promote tumorigenesis. Here we report that PDK1 directly induces phosphorylation of Polo-like kinase 1 (PLK1), which in turn induces Myc ...
ORGANISM(S): Homo sapiens 
2013-07-31 | E-GEOD-30669 | biostudies-arrayexpress
TranscriptomicsMechanosensitive proteins are sensitized in myelinated afferents following in vivo inflammation
Here we identified two populations of myelinated sensory neurons that display markedly different phenotypes in terms of their action potential characteristics and responses to mechanical stimuli based on their expression of Calcitonin Gene-Related Peptide (CGRP). Myelinated neurons that did not expr...
ORGANISM(S): Mus musculus 
2015-11-06 | E-GEOD-65613 | biostudies-arrayexpress
UnknownHigh Frequency and Poor Outcome of Philadelphia Chromosome-Like Acute Lymphoblastic Leukemia in Adults.
Not available
S-EPMC5455698 | biostudies-literature
TranscriptomicsReal-time quantitative PCR analysis of hormone-receptor-negative primary breast tumors
Total RNA was extracted from FFPE samples of 139 chemotherapy-naïve hormone-receptor-negative breast cancers pooled from three sample sources and assayed for the expression of 21 genes within two previously reported microarray-derived prognostic signatures in 6 RT-PCR multiplexes. RT-PCR gene expre...
ORGANISM(S): Homo sapiens 
2013-10-25 | E-GEOD-51630 | biostudies-arrayexpress
ProteomicsConstrained self-antigen presentation in thymus underlies initiation of tissue-targeted autoimmunity
Presentation of tissue-restricted antigens (TRA) in the thymus is essentialfor establishing self-tolerancethrough elimination of autoreactive Tcells.It remains unclear why certain self T cells can bypassthymic selectionand become driversoftissue-specific autoimmunity. Herewe assessedthy...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD030999 | Pride
Mouse Thymus Crinosomes 
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