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ProteomicsInsulin Granule and Secreted Peptidome
Insulin peptidome, for dense core granules, crinosomes and secretome, was characterized by nLC-MS/MS.
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2018-07-23 | PXD009919 | Pride
Nlc-ms/ms Mouse Human Insulin Type 1 diabetes 
ProteomicsIdentification of spliced peptides in pancreatic islets uncovers errors leading to false assignments
Spliced peptides have been identified in the class I major histocompatibility complex (MHC) peptidomes of several tumors and have emerged as novel autoantigens that can stimulate highly specific T cells. A special class of spliced peptides, hybrid insulin peptides (HIPs), bound to histocompatibility...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2021-02-11 | PXD019819 | Pride
Mhc-i peptidome Crinosomes 
ProteomicsConstrained self-antigen presentation in thymus underlies initiation of tissue-targeted autoimmunity
Presentation of tissue-restricted antigens (TRA) in the thymus is essentialfor establishing self-tolerancethrough elimination of autoreactive Tcells.It remains unclear why certain self T cells can bypassthymic selectionand become driversoftissue-specific autoimmunity. Herewe assessedthy...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-22 | PXD030999 | Pride
Mouse Thymus Crinosomes 
UnknownThe Ykt6-Snap29-Syx13 SNARE complex promotes crinophagy via secretory granule fusion with Lamp1 carrier vesicles.
Not available
S-EPMC10853563 | biostudies-literature
UnknownMapping of a hybrid insulin peptide in the inflamed islet β-cells from NOD mice.
Not available
S-EPMC10917911 | biostudies-literature
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