Sort   by:  
 Page size 
ProteomicsSUMO Proteomics Analyses Identify Protein Inhibitor of Activated STAT-Mediated Regulatory Networks Involved in Cell Cycle and Cell Proliferation
Protein inhibitor of activated STAT (PIAS) are E3 SUMO ligases playing important roles in protein stability and signaling transduction pathways. PIAS proteins are overexpressed in the triple-negative breast cancer cell line MDA-MB-231, and PIAS knockout (KO) results in a reduction in cell proliferat...
ORGANISM(S): Homo sapiens (Human) 
2023-02-02 | PXD023841 | Pride
Hek293 sumo3m lc-ms/ms pias sumo e3 ligase proteomics 
ProteomicsA short SUMOylation tag modulates transcription factor activity
This research demonstrates that a short peptide, composed of residues 24-55 of ZNF451, is sufficient to induce SUMOylation of target proteins, both in vitro and in human cells. Increased SUMOylation of the transcription factor p53 via fusion with the ZNF451 peptide inhibits its transcriptional activ...
ORGANISM(S): Homo sapiens (Human) 
2025-12-01 | PXD068083 | Pride
Sumo e3 ligase Small ubiquitin-like modifier (sumo) Transcription factor Sumoylation tag Znf451 Sumoylation P53 
ProteomicsA ZNF-nanobody fusion reveals SUMOylation-dependent changes in protein localization
SUMOylation is a post-translational modification regulating protein localization, stability, and activity, with effects varying depending on the identity of the conjugated SUMO protein (SUMO1 or SUMO2/3) and type of SUMOylation (mono-, multi-, or poly-). We previously developed a small 32 amino acid...
ORGANISM(S): Homo sapiens (Human) 
2026-03-24 | PXD069854 | Pride
ProteomicsMulti-omics analysis of human peripheral blood reveals marked molecular profiling changes caused by one night of sleep deprivation
Sleep insufficiency is associated with various disorders (cardiovascular disease, neurodegenerative diseases, immunological disorders.) but the molecular bases for these associations are largely unknown. We used multiple omics techniques to examine changes in the blood of healthy male and female adu...
ORGANISM(S): Homo Sapiens 
PXD033402 |
ProteomicsCross-link of Drosophila P75 dimer
Use XL-MS to detect whether dP75 can form homodimer
ORGANISM(S): Drosophila Melanogaster 
2024-12-12 | PXD058799 |
ProteomicsA classic famous prescription alleviates inflammation in CUMS model mice via modulating MYDGF/MAP4K4/NF-κB signaling pathway, verified through UPLC-HRMS and proteomics analysis
Major depressive disorder (MDD) has caused a heavy burden on society and affected over 350 million patients worldwide currently. However, there have been 30-50% MDD patients with non-response to antidepressants. Chronic unpredictable mild stress (CUMS) has been considered as a critical trigger facto...
ORGANISM(S): Mus Sp. 
PXD053391 |
ProteomicsA phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming upon chitin perception
OsRLCK185 is a functional kinase, we then examined whether OsRLCK185 phosphorylates OsPUB20 using an in vitro kinase assay, OsRLCK185K108A served as a negative control. The results showed that GST-OsRLCK185, but not GST-OsRLCK185K108A, phosphorylates OsPUB20 in vitro. Using LC-MS/MS analysis after a...
ORGANISM(S): Oryza Sativa 
2026-01-29 | PXD073757 |
ProteomicsA phosphorylation-dependent ubiquitination switch orchestrates nuclear immune reprogramming
The nuclear localization of OsGF14f is crucial for blast resistance. To understand how OsGF14f functions in the nucleus to modulate blast resistance, we identified OsGF14f-interacting proteins by LC-MS/MS assays with OsGF14f-GFP plants. Among the candidate proteins, a nuclear-localized protein was O...
ORGANISM(S): Oryza Sativa 
2026-01-29 | PXD073756 |
Sort   by:  
 Page size