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ProteomicsCDK12 and Integrator-PP2A complex Modulates LEO1 Phosphorylation for Processive Transcription Elongation
Cyclin-dependent kinase 12 (CDK12) interacts with Cyclin K to form a functional nuclear kinase that promotes processive transcription elongation through phosphorylation of the RNA polymerase II (Pol II) C-terminal domain (CTD). To gain a broader understanding of CDK12 cellular function, we used chem...
ORGANISM(S): Homo sapiens (Human) 
2023-06-08 | PXD038558 | Pride
Cdk12 Transcription elongation Analog-sensitive kinase Rna polymerase ii Leo1 Paf1 complex Intac complex 
ProteomicsThe strategy of a novel way to enhance bacterial motility
Bacterial motility shows a strong evolvable feature depending on the environment. Hyper-motile E. coli could be isolated by evolving non-motile E. coli due to the mutations that enhanced transcriptional expression of the master regulator of the flagellum biosynthesis, FlhDC. These hyper-motile isola...
ORGANISM(S): Escherichia coli 
2021-11-25 | PXD023645 | Pride
Swimming motility  flagella  clpx  trade-off 
ProteomicsCo-immunoprecipitation of G-quadruplex-containing Core Promoter and nanoLC-FAMIS-MS/MS
G-quadruplexes (G4s) are noncanonical DNA secondary structures formed through the self-association of guanines, and they are distributed widely across the genome. G4 participates in multiple biological processes including gene transcription, and G4-targeted ligands serve as potential therapeutic age...
ORGANISM(S): Homo sapiens (Human) 
2021-07-19 | PXD026830 | Pride
Human Core promoter Co-immunoprecipitation G-quadruplex Nuclear protein Nanolc-famis-ms/ms 
ProteomicsIntegrated Analysis of Laminin Subunit Beta 1 Impact on Subchorionic Hemorrhage: Insights into Inflammation and Thrombosis Pathways
Subchorionic hemorrhage (SCH) is characterized by a fluid-filled hypoechoic area in early pregnancy. This study investigates how laminin subunit β1 (LAMB1) modulates type III collagen (COL3A1) and Rac family small GTPase 1 (RAC1) in SCH coagulation and immunity.
ORGANISM(S): Homo Sapiens 
2025-12-03 | PXD071504 |
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