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ProteomicsKK-LC-1 as a feasible therapeutic target to eliminate ALDH+ stem cells in triple negative breast cancer
Failure to achieve complete elimination of triple negative breast cancer (TNBC) stem cells after adjuvant therapy is associated with poor outcomes. Aldehyde dehydrogenase 1 (ALDH1) is a marker of breast cancer stem cells (BCSCs), and its enzymatic activity regulates tumor stemness. Identifying upstr...
ORGANISM(S): Homo sapiens (Human) 
2023-04-12 | PXD040200 | Pride
Cancer stem cell Tnbc Hippo signaling pathway Aldh+ stemness Protein-protein inhibitor. 
ProteomicsThe mass spectrometry analysis of CTDP1 function
We previously identified an interaction between the RNA polymerase II (Pol II) subunit RPB7 and the phosphatase CTDP1 in regulating transcription termination-reinitiation. Here, we establish that CTDP1 dephosphorylates a unique Pol II phospho-isoform modified at Tyr1, Ser5, and Ser7 of its C-termina...
ORGANISM(S): Mus musculus (Mouse) Homo sapiens (Human) 
2026-07-10 | PXD071392 | Pride
Pol ii Mediator Ctdp1 
Proteomics4D label-free quantitative proteomics analysis of collagen-induced arthritis rats
4D label-free quantitative proteomics was performed to analysis the changes of protein expression in synovial tissues between Normal control group, Model control group and JTQBG treated group.
ORGANISM(S): Rattus Norvegicus 
2024-02-23 | PXD050056 |
ProteomicsTargeted protein degradation reveals Pol II heterogeneity and functional diversity
RNA polymerase II (Pol II) subunits are thought to be involved in various transcription-associated processes, but it is unclear whether they play different regulatory roles in modulating gene expression. Here, we performed nascent and mature transcript sequencing after the acute degradation of 12 ma...
ORGANISM(S): Mus <genus> 
2022-08-09 | PXD035866 |
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