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TranscriptomicsA Global Genomic View of MIF Knockdown Cell
siRNA-mediated knockdown of MIF expression in HEK293 cells resulted in inhibition of cell proliferation and cell cycle progress. The microarray study of MIF KD cells reveald knockdown of MIF would lead to extensive changes in gene expression profiles which may elucidate the molecular mechanism of...
ORGANISM(S): Homo sapiens 
2009-11-02 | E-GEOD-10241 | biostudies-arrayexpress
TranscriptomicsTranscriptome response to salinity stress in the Pacific oyster Crassostrea gigas
Low salinity is one of the main factors limiting the distribution and survival of marine species. As a euryhaline species, the Pacific oyster Crassostrea gigas can be tolerant to relative low salinity. Through Illumina sequencing, we generated two transcriptomes with samples taken from gills of oyst...
ORGANISM(S): Crassostrea gigas 
2012-12-15 | E-GEOD-38022 | biostudies-arrayexpress
MetabolomicsAcupuncture Synergized With Bortezomib Improves Survival of Multiple Myeloma Mice via Decreasing Metabolic Ornithine
Multiple myeloma (MM) is a hematological malignancy worldwide in urgent need for novel therapeutic strategies. Since Velcade (bortezomib) was approved for the treatment of relapsed/refractory MM in 2003, we have seen considerable improvement in extending MM patient survival. However, most patients a...
2022-02-21 | MTBLS3487 | MetaboLights
ProteomicsIntact mass spectrometry analysis of covalent binding between purified recombinant human FGFR2 V564F protein and small-molecule compound LC-F2-1 incubated at a molar ratio of 1:2 or 1:5 at room temperature via Agilent 6230 time-of-flight LC/MS system for the characterization of their covalent binding products in protein-drug interaction studies
This dataset corresponds to an intact mass spectrometry study focusing on the covalent binding interaction between purified FGFR2 V564F protein and compound LC-F2-1. The purified FGFR2 V564F was adjusted to 28 μM, then incubated with LC-F2-1 at molar ratios of 1:2 or 1:5 for 4 hours at room temperat...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD073416 | Pride
Covalent binding Lc-ms Lc-f2-1 Fgfr2 v564f 
TranscriptomicsTranscriptome response to salinity stress in Crassostrea hongkongensis
Low salinity is one of the main factors limiting the distribution and survival of marine species. As estuarine species, Crassostrea hongkongensis can live in relative low salinity. Through Illumina sequencing, we generated two transcriptomes with samples taken from gills of oysters exposed to the lo...
ORGANISM(S): Crassostrea hongkongensis 
2014-10-01 | E-GEOD-51157 | biostudies-arrayexpress
TranscriptomicsEffect of TGF-B treatment on human vascular smooth muscle cells
The authors did a microarray analysis to investigate the effect of TGF-B treatment on cultured smooth muscle cells from the human aorta. In particular, the authors were interested to see which cell types were upregulated or downregulated after treatment with TGF-B. Human Smooth muscle cells from 4 d...
ORGANISM(S): Homo sapiens 
2011-06-16 | E-GEOD-30004 | biostudies-arrayexpress
ProteomicsLyn attenuates cisplatin-induced acute kidney injury by inhibition of RIPK1-mediated apoptosis and necroptosis
Our study revealed that Lyn protects from cisplatin-induced nephrotoxicity by suppressing RIPK1-mediated apoptosis, necroptosis and inflammation.
ORGANISM(S): Mus Musculus 
2026-05-16 | PXD078460 |
ProteomicsTransketolase promotes MAFLD by limiting inosine-induced mitochondrial activity (Proteomics)
Metabolic dysfunction-associated fatty liver disease (MAFLD) has a global prevalence of about 25% and no approved therapy. Using metabolomic and proteomic analyses, we identified high expression of hepatic transketolase (TKT), a metabolic enzyme of the pentose phosphate pathway, in human and mouse M...
ORGANISM(S): Homo Sapiens 
2024-02-26 | PXD050130 |
ProteomicsUBA2-High Osteosarcoma Suppresses Immune Infiltration by Autophagy-Mediated MHC-I Degradation
Osteosarcoma (OS) responds poorly to immune-checkpoint blockade (ICB), and the molecular drivers of its immune-cold state remain unclear. Using multi-omics analyses, we identified an immune-cold OS subtype characterized by enrichment of protein SUMOylation and found the SUMO E1 subunit UBA2 as a key...
ORGANISM(S): Homo Sapiens 
2026-01-28 | PXD073700 |
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