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MetabolomicsSMN deficiency perturbs monoamine neurotransmitter metabolism in spinal muscular atrophy

Beyond motor neuron degeneration, homozygous mutations in the survival motor neuron 1 (SMN1) gene cause multiorgan and metabolic defects in patients with spinal muscular atrophy (SMA). However, the precise biochemical features of these alterations and the age of onset in the brain and peripheral ...

2023-11-27 | MTBLS8784 | MetaboLights
UnknownPrediction of P-tau/Aβ42 in the cerebrospinal fluid with blood microRNAs in Alzheimer's disease.
Not available
S-EPMC8591889 | biostudies-literature
UnknownProteomic profiling of circulating plasma exosomes reveals novel biomarkers of Alzheimer's disease.
Not available
S-EPMC9720984 | biostudies-literature
UnknownAssociation of accelerated long-term forgetting and senescence-related blood-borne factors in asymptomatic individuals from families with autosomal dominant Alzheimer's disease.
Not available
S-EPMC8157428 | biostudies-literature
UnknownDetection of plasma Aβ seeding activity by a newly developed analyzer for diagnosis of Alzheimer's disease.
Not available
S-EPMC8808989 | biostudies-literature
ProteomicsPrenylated flavonoids from Sophora flavescens (Kushen) inhibit hepatocellular carcinoma growth by suppressing the Akt/MDM2/p53 pathway to activate mitochondrial apoptosis
Background: Hepatocellular carcinoma (HCC) remains a global health challenge with limited treatment options and frequent development of drug resistance. Sophora flavescens, a traditional Chinese medicine, contains prenylated flavonoids with documented antitumor potential, though their in vivo effica...
ORGANISM(S): Homo Sapiens 
2025-12-22 | PXD072322 |
ProteomicsFatty Acid Metabolism Reprograms Immune Microenvironment in Retinal Artery Occlusion: Multi-Omics Analysis Highlights Immunometabolic Crosstalk
This dataset contains integrated multi-omics data from a study investigating fatty acid metabolism and immune dysregulation in retinal artery occlusion (RAO). Data include serum metabolomics profiles, peripheral blood mononuclear cell (PBMC) transcriptomics, and immune phenotyping from 66 RAO patien...
ORGANISM(S): Homo Sapiens 
2026-04-19 | PXD077366 |
MetabolomicsHarnessing Exogenous Stimuli and Functionally 3D Aligned Fibrous Scaffolds for Spatiotemporal Modulation of Bone Regeneration

Bone regeneration requires spatiotemporal coordination of immune modulation, stem cell recruitment, angiogenesis, and osteogenesis, yet most scaffolds lack sequential control across healing phases. We develop a near-infrared (NIR)-responsive therapeutic platform that integrates clinically av...

2026-03-04 | MTBLS13974 | MetaboLights
ProteomicsProteomic Profiling and Biomarker Discovery for Predicting Response to PD-1 Inhibitor Immunotherapy in Gastric Cancer Patients
Revolutionizing cancer treatment, immune checkpoint inhibitors (ICIs) have nonetheless encountered a challenge: a substantial portion of gastric cancer (GC) patients don’t respond to this therapy. This pressing issue necessitates a deeper understanding of the resistance mechanisms against ICIs and t...
ORGANISM(S): Homo Sapiens 
2024-02-29 | PXD050228 |
ProteomicsThe differential proteins in dairy cow placental trophoblast cells-derived exosomes between P4 treatment and non P4 treatment
Inadequate fetomaternal interactions could directly lead to pregnancy failure in dairy cows. Exosomes are widely involved in endometrial matrix remodeling, immune function changes, placental development, and other processes of embryo implantation and pregnancy in dairy cows. However, the role of e...
ORGANISM(S): Bos Taurus 
2021-12-21 | PXD030586 |
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