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ProteomicsSingle-copy locus proteomics of early- and late-firing DNA replication origins identifies a role of Ask1/DASH complex in replication timing control
The chromatin at origins of replication is thought to influence DNA replication initiation in eukaryotic genomes. However, it remains unclear how the chromatin composition controls the firing of early-efficient (EE) or late-inefficient (LI) origins. Here, we used site-specific recombination and sing...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-02-16 | PXD032930 | Pride
Locus-specific chromatin isolation  site-specific recombination  affinity purification  dna replication origin  replication timing  replication efficiency  origin chromatin structure  dash complex  ask1 protein  microtubule cytoskeleton 
MetabolomicsMaHPIC Experiment HuC - Metabolomics of plasma samples from human volunteers infected with Plasmodium vivax
Project Description:
The Malaria Host-Pathogen Interaction Center (MaHPIC) is a transdisciplinary malaria systems biology research program initially supported by an NIH/NIAID contract (HHSN272201200031C, 2012-2017; see http://w...
2018-06-19 | MTBLS665 | MetaboLights
MetabolomicsMaHPIC Experiment HuB - Metabolomics analysis of human plasma from patients infected with Plasmodium falciparum and P.vivax for discovery of diagnostic markers of malaria
MaHPIC Experimental Description:
This study is based on archived plasma from samples collected between 2011 and 2014. Patients in Thailand who were infected with Plasmodium falciparum (30 subjects), P. vivax (30 subjects), co-infected with P. falciparum and P. viv...
2018-09-05 | MTBLS664 | MetaboLights
UnknownGlycyrrhizic Acid Prevents Sepsis-Induced Acute Lung Injury and Mortality in Rats.
Not available
S-EPMC4812678 | biostudies-literature
ProteomicsSingle-copy locus isolation identifies distinct proteomes of early- and late-firing DNA replication origin chromatin
The chromatin at origins of replication is the template for DNA replication initiation in eukaryotic genomes. However, whether the chromatin composition instructs individual origins to fire early-efficiently (EE) or late-inefficiently (LI) remains to be investigated. Here, we used site-specific reco...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2023-05-10 | PXD031984 | Pride
Replication timing Replication efficiency Affinity purification Locus-specific chromatin isolation Dna replication origin Histone ptms Site-specific recombination 
UnknownDifferential expression of IRF8 in subsets of macrophages and dendritic cells and effects of IRF8 deficiency on splenic B cell and macrophage compartments.
Not available
S-EPMC2745513 | biostudies-literature
UnknownMitoTracker Red for isolation of zone-specific hepatocytes and characterization of hepatic sublobular metabolism.
Not available
S-EPMC11532002 | biostudies-literature
MetabolomicsMultiyear dynamics of recent and legacy contaminants in a German hill-slope catchment (MS2 data)

Anthropogenic activities cause the release of vast amounts of contaminants into the environment and thus also into surface- and groundwaters. Regulatory monitoring determines whether critical threshold concentrations are surpassed, by mostly occasional probing. This irregular testing, however, do...

2024-06-04 | MTBLS3533 | MetaboLights
ProteomicsMouse Model of Alzheimer’s Disease Demonstrates Differential Effects of Early Pathology on Various Brain Regions
Alzheimer’s disease (AD) is a chronic ageing related neurodegenerative disease which is characterized by loss of synapses and neurons in the vulnerable brain regions. Expression perturbations of amyloid β (Aβ) and tau protein in the brain are two hallmarks of AD. Aβ is abnormally generated from amyl...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-11 | PXD019192 | Pride
Proteomics Hippocampus Alzheimer’s disease Cerebellum Amyloid beta Cortex App/ps1 
UnknownAssessing Region of Interest Schemes for the Corticospinal Tract in Patients With Brain Tumors.
Not available
S-EPMC4998407 | biostudies-literature
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