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ProteomicsIdentification of novel 53BP1 associated proteins
We used homologous recombination based CRISPR Knock-in strategy to insert a SFB tag at C terminal of 53BP1 in 293T cells. We performed tandem affinity purification of endogenous 53BP1 in both soluble and chromatin fraction to uncover known and new 53BP1 binding proteins which might play roles in DNA...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD020090 | Pride
53bp1 
ProteomicsP. micra surface protein TmpC interacts directly with OSCC cell lines via CKAP4
P. micra surface protein TmpC interacts directly with OSCC cell lines via CKAP4, a receptor frequently overexpressed in human OSCC tumors. The interaction of TmpC and CKAP4 mediates bacterial attachment, invasion, and metastasis-promoting effects of P. micra on OSCC and subsequently activates HIF-1α...
ORGANISM(S): Homo Sapiens 
PXD054166 |
ProteomicsA CHKA–PML autophagy checkpoint enables tumors to evade glutamine starvation
CHKA phosphorylates PML at Tyr339 to promote its cytoplasmic localization; cytoplasmic PML then induces WIPI2 SUMOylation at Lys281/283, blocking HUWE1-mediated degradation. Stabilized WIPI2 enhances autophagic flux and supports tumor cell survival under metabolic stress.
ORGANISM(S): Homo Sapiens 
2026-03-03 | PXD075116 |
ProteomicsQuantitative proteomic analysis of targeted degradation following Pep-TAC treatment
Quantitative proteomic analysis raw data for the manuscript entitled “A covalent peptide-based lysosome-targeting protein degradation platform for cancer immunotherapy”.
ORGANISM(S): Homo Sapiens Mus Musculus 
2025-01-22 | PXD060051 |
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