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TranscriptomicsTranscriptional profiling of the tuberculin skin test in healthy volunteers and in rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy
Anti-TNF therapy has transformed the management of rheumatoid arthritis (RA); however little is known about its effects on cell mediated immune responses and TNF-inducible activity at the site of inflammation. Here, we used the tuberculin skin test (TST) as a standardised in vivo human challenge mod...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5093 | biostudies-arrayexpress
MetabolomicsMetabolomic Characterization of Knock-Out Mutants in Arabidopsis - Development of a Metabolite Profiling Database for Knock-Out Mutants in Arabidopsis (MeKO)
Despite recent intensive research efforts in functional genomics, the functions of only a limited number of Arabidopsis (Arabidopsis thaliana) genes have been determined experimentally. Thus, improving gene annotation remains a major challenge in plant science. Because metabolite profiling can chara...
2014-03-01 | MTBLS47 | MetaboLights
TranscriptomicsGSTP1 expression predicts poor pathological complete response to neoadjuvant chemotherapy in ER-negative breast cancer
The purpose of the present study was to investigate the association of glutathione S-transferase P1 (GSTP1) expression with resistance to neoadjuvant paclitaxel followed by 5-fluorouracil/epirubicin/cyclophosphamide (P-FEC) in human breast cancers. The relationship of GSTP1 expression and GSTP1 prom...
ORGANISM(S): Homo sapiens 
2012-03-20 | E-GEOD-32646 | biostudies-arrayexpress
GenomicsPaternally-induced transgenerational environmental reprogramming of metabolic gene expression in mammals (meDIP)
Epigenetic information can be inherited through the mammalian germline, and represents a plausible transgenerational carrier of environmental information. To test whether transgenerational inheritance of environmental information occurs in mammals, we carried out an expression profiling screen for g...
ORGANISM(S): Mus musculus 
2011-01-14 | E-GEOD-25898 | biostudies-arrayexpress
TranscriptomicsPseudomonas aeruginosa PA14 differential gene expression in bqsR (PA14_29730) mutants
Before and after anaerobic Fe(II) shocked WT and M-bM-^HM-^FbqsR of late stationary phase P. aeruginosa PA14 strains Associated publication: Kreamer NN, Costa F, Newman DK. 2015. The ferrous iron-responsive BqsRS two-component system activates genes that promote cationic stress tolerance. mBio 6(1):...
ORGANISM(S): Pseudomonas aeruginosa 
2015-02-01 | E-GEOD-65393 | biostudies-arrayexpress
TranscriptomicsDiv-Seq: Single-nucleus RNA-Seq reveals dynamics of rare adult newborn neurons
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2016-08-16 | E-GEOD-84371 | biostudies-arrayexpress
TranscriptomicsSingle nuclei RNA-seq from adult mouse Hippocampus
We report RNA-seq of single nuclei isolated from the adult C57BL/6 male mouse Hippocampus region. Majority of the nuclei were isolated from 12 weeks old mice (4 different animal), with an additional set of nuclei from 3 months and 2 years old animals. In addition a set of GFP labeled nuclei driven b...
ORGANISM(S): Mus musculus 
2016-08-16 | E-GEOD-85721 | biostudies-arrayexpress
TranscriptomicsWhole blood transcriptional profiling of healthy volunteers and rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy after ex vivo whole blood stimulation with TNF
We tested the hypothesis that anti-tumor necrosis factor (TNF) therapy reduces TNF-inducible gene expression in blood. Whole peripheral blood from healthy volunteers and rheumatoid arthritis patients (treated with the monoclonal anti-TNF antibody adalimumab, the soluble TNF receptor etanercept or th...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5094 | biostudies-arrayexpress
UnknownGenetic association analysis of 30 genes related to obesity in a European American population.
Not available
S-EPMC3909018 | biostudies-literature
UnknownProspective study evaluating the impact of tissue confirmation of metastatic disease in patients with breast cancer.
Not available
S-EPMC5015424 | biostudies-literature
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