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ProteomicsTargeted Proteomics Reveals Quantitative Differences in Low Abundance Glycosyltransferases of Patients with Congenital Disorders of Glycosylation
Protein glycosylation is an essential posttranslational modification in all domains of life. Its impairment in human can result in severe diseases named Congenital Disorders of Glycosylation (CDGs). Most of the glycosyltransferases (GTs) responsible for proper glycosylation are polytopic membrane p...
ORGANISM(S): Homo Sapiens 
2024-01-30 | PXD048072 | panorama
TranscriptomicsHomeostatic skin contains two different subsets of resident macrophages with distinct origin and gene profile.
We have found the existence of two independent populations contributing to the skin-resident macrophage pool based on their different origin. We have analyzed their gene profile by deep-sequencing (RNA-Seq). Analysis of RNA-Seq data revealed a differential expression signature between both subsets o...
ORGANISM(S): Mus musculus 
2016-07-26 | E-GEOD-50566 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of reactive stroma in prostate cancer
This is an analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched normal peripheral zone tissues. Keywords: two group comparison Laser capture microdissection and expression array analysis of stroma from 17 Grade 3 reactive stroma prostate cancer tissues and matched ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-11682 | biostudies-arrayexpress
TranscriptomicsGene expression signature predicts induction treatment response and clinical outcome in adult Colombian patients with B-acute lymphoblastic leukemia
Background. B-Acute lymphoblastic leukemia (B-ALL) represents a hematologic malignancy with poor clinical outcome and low survival rates in adult patients. Only 61% of Colombian adult patients with ALL achieve complete remission and a median overall survival of less than 11.3 months and event-free s...
ORGANISM(S): Homo sapiens 
2016-04-06 | E-GEOD-76349 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of PNT1a prostate cells expressing FGFR-4 Arg388 or Gly388.
We have shown that in PNT1a cells expressing exogenous FGFR4 Arg388 or Gly388 under the control of the EF1 promoter almost all FGFR signaling can be attributed to the transfected receptor, and the two FGFR-4 isoforms are expressed at equivalent levels in the two cell lines. Furthermore, we have show...
ORGANISM(S): Homo sapiens 
2011-07-01 | E-GEOD-20906 | biostudies-arrayexpress
TranscriptomicsNext generation sequencing profiling identifies miR-574-3p and miR-660-5p as potential novel prognostic markers for breast cancer
Prognostication of Breast Cancer (BC) relies largely on traditional markers such as hormone or growth factors but due to their suboptimal specificities, it is challenging to identify the subset of patients who are likely to undergo recurrence and markers of higher specificity are sought to guide the...
ORGANISM(S): Homo sapiens 
2016-03-02 | E-GEOD-68085 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [EVI1_ST]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-08 | E-GEOD-39103 | biostudies-arrayexpress
TranscriptomicsGene expression changes induced by overexpression of EVI1 in Lin- hematopoietic cells [Lin]
The transcription factor Evi1 is essential for the formation and maintenance of hematopoietic stem cells, and induces clonal dominance with malignant progression upon constitutive activation by chromosomal rearrangements or transgene integration events. To understand the immediate and adaptive respo...
ORGANISM(S): Mus musculus 
2013-01-09 | E-GEOD-34729 | biostudies-arrayexpress
ProteomicsLISS enables immune evasion of colorectal cancers irrespective of MSI status
LISS enables immune evasion of colorectal cancers irrespective of MSI status
ORGANISM(S): Homo Sapiens 
PXD078805 |
TranscriptomicsEffects of FGF2 and cell culture surface on the transcriptome of adult human dermal fibroblasts
The current study set to determine the effects of Fibroblast Growth Factor 2 and cell culture surface (tissue culture plastic and glass) on the transcriptome of adult human dermal fibroblasts. Transcriptional profiles of adult human dermal fibroblasts grown in four experimental conditions (glass, gl...
ORGANISM(S): Homo sapiens 
2013-10-15 | E-GEOD-48967 | biostudies-arrayexpress
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