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UnknownDose escalation to rash for erlotinib plus gemcitabine for metastatic pancreatic cancer: the phase II RACHEL study.
Not available
S-EPMC4260026 | biostudies-literature
TranscriptomicsA novel method of amplification of FFPET derived-RNA enables accurate disease classification with microarrays
A new method for amplification and labeling of RNA is assessed that permits gene expression microarray analysis of formalin-fixed paraffin embedded tissue (i.e. FFPET) samples. Valid biological data was obtained using gene expression microarrays of diffuse large B-cell lymphoma (i.e. DLBCL) FFPET sa...
ORGANISM(S): Homo sapiens 
2010-06-09 | E-GEOD-19246 | biostudies-arrayexpress
TranscriptomicsIdentifying host pathogenic pathways in bovine digital dermatitis by RNA-Seq analysis of lesions
Digital dermatitis is a painful foot disease compromising welfare in dairy cattle. The disease has a complex multibacterial aetiology, but little is known about its pathogenesis. In this study, gene expression in skin biopsies from five bovine digital dermatitis lesions and five healthy bovine feet ...
ORGANISM(S): Bos taurus 
2013-03-26 | E-GEOD-41732 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of the tuberculin skin test in healthy volunteers and in rheumatoid arthritis patients treated with methotrexate or anti-TNF therapy
Anti-TNF therapy has transformed the management of rheumatoid arthritis (RA); however little is known about its effects on cell mediated immune responses and TNF-inducible activity at the site of inflammation. Here, we used the tuberculin skin test (TST) as a standardised in vivo human challenge mod...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5093 | biostudies-arrayexpress
Genomicsena-DATASET-LUDJHU-22-08-2017-18:25:45:667-381 - samples
Samples prepared using Safe-SeqS technology. All samples ran on an Illumina MiSeq instrument. Fastq files for read 1 and the index read present (R and I respectively).
EGAD00001003579 | EGA
UnknownSystematic Review of Prevalence of Young Child Overweight and Obesity in the United States-Affiliated Pacific Region Compared With the 48 Contiguous States: The Children's Healthy Living Program.
Not available
S-EPMC4265894 | biostudies-literature
ProteomicsProteomic profiling of kidney biopsies in nephrotic syndrome
Minimal change disease (MCD) and focal segmental glomerulosclerosis (FSGS) are patterns of kidney injury observed in the filtering units of the kidney known as glomeruli. From the NURTuRE cohort of individuals with nephrotic syndrome (NS), we performed laser microdissection and mass spectrometry ana...
ORGANISM(S): Homo sapiens (Human) 
2024-07-15 | PXD053362 | Pride
Nurture cohort Laser-microdissection Global proteomics Minimal change Focal segmental glomerulosclerosis Nephrotic syndrome 
TranscriptomicsDifferential gene expression in the skin of dogs sensitized to the house dust mite Dermatophagoides farinae
Atopic dermatitis is a multifactorial allergic skin disease in humans and dogs. Genetic predisposition, immunologic hyperreactivity, a defective skin barrier and environmental factors play a role in its pathogenesis. The aim of this study was to analyze gene expression in the skin of dogs sensitized...
ORGANISM(S): Canis lupus familiaris 
2014-09-23 | E-GEOD-58442 | biostudies-arrayexpress
TranscriptomicsTranscriptional response of LPS-stimulated monocyte-derived macrophages in the presence or absence of the anti-TNF agonist Etanercept
We measured TNFα activity on the transcriptional level by identifying TNFα-inducible genes in human blood monocyte-derived macrophages (MDM). On the basis that TNFα does not act in isolation, we used bacterial lipopolysaccharide (LPS) as a prototypic model of a stimulus to invoke secretion of a w...
ORGANISM(S): Homo sapiens 
2017-08-04 | E-MTAB-5095 | biostudies-arrayexpress
ProteomicsHuman skin fibroblast proteome in healthy aging
The changes in the proteome of different human tissues with advancing age are poorly characterized. Here, we studied the proteins present in skin fibroblasts collected from 82 healthy individuals across a wide age spectrum (22 to 89 years old) who participated in the GESTALT (Genetic and Epigenetic...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-17 | MSV000088401 | MassIVE
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