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GenomicsTranscriptional regulation by H3K122 acetylation in the lateral surface of the histone octamer
We characterize the acetylation of H3K122 for the first time. Towards this we mapped the genomic distribution of H3K122Ac, identified the enzyme introducing H3K122Ac, and addressed the functional contribution H3K122Ac to transcription. We found that H3K122Ac is associated with chromatin marks and ge...
ORGANISM(S): Homo sapiens 
2013-02-14 | E-GEOD-35954 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP6.0 array data for different clinical outcomes of HBV infection
Chronic hepatitis B virus (HBV) infection is a serious global public health problem. To identify susceptibility loci for disease progression of HBV infection, we performed this genome-wide association study using DNA pools of case and control constructed by progressed HBV carriers (acute liver failu...
ORGANISM(S): Homo sapiens 
2013-12-10 | E-GEOD-26034 | biostudies-arrayexpress
GenomicsGenome-Wide Association Studies in Upper Gastrointestinal Cancers (Asian)

This project aims to conduct genome-wide association studies (GWAS) in two anatomically different upper gastrointestinal (UGI) cancer sites in two populations with distinctly different disease rates and genetic profiles. One population has very high rates for both esophageal squamous cel...

phs000361.v1.p1 | EGA
UnknownPlasma miR-142 predicts major adverse cardiovascular events as an intermediate biomarker of dual antiplatelet therapy.
Not available
S-EPMC6329771 | biostudies-literature
TranscriptomicsAberrantly microRNA profiling in cancerous hepatocytes versus normal primary hepatocytes
MicroRNAs is a rapidly expanding area expected to change the way in which diseases will be diagnosed, treated and monitored in the future. Hepatocellular carcinoma (HCC) shows a rising incidence with high mortality but lack of effective targeted therapies. We identified the aberrantly expressed miRN...
ORGANISM(S): Homo sapiens 
2010-12-30 | E-GEOD-20077 | biostudies-arrayexpress
TranscriptomicsMiR-192 inhibits nucleotide excision repair by targeting ERCC3 and ERCC4 in HepG2.2.15 cells.
Deficient DNA repair capacity is associated with genetic lesions accumulation and susceptibility to carcinogenesis. MicroRNAs (miRNAs) are small non-coding RNAs that regulate various cellular pathways including DNA repair. Here we hypothesized that the existence of HBV products may interfere with ce...
ORGANISM(S): Homo sapiens 
2011-08-02 | E-GEOD-27561 | biostudies-arrayexpress
TranscriptomicsA long noncoding RNA protects the heart from pathological hypertrophy
The role of long noncoding RNA (lncRNA) in adult hearts is unknown; also unclear is how lncRNA modulates nucleosome remodelling. An estimated 70% of mouse genes undergo antisense transcription1, including myosin heavy chain 7 (Myh7), which encodes molecular motor proteins for heart contraction2. Her...
ORGANISM(S): Homo sapiens 
2014-08-05 | E-GEOD-49716 | biostudies-arrayexpress
TranscriptomicsReprogramming fibroblasts into bi-potential hepatic stem cells by defined factors
Recent studies have demonstrated direct reprogramming of fibroblasts into a range of somatic cell types, but to date stem/progenitor cells have only been reprogrammed for the blood and neuronal lineages. We previously reported generation of induced hepatocyte-like (iHep) cells by transduction of Gat...
ORGANISM(S): Mus musculus 
2013-07-19 | E-GEOD-48486 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of the mouse oviduct during the estrous cycle
This study attempted to reveal the profile of the oviductal gene expression at each stage of estrous cycle by microarray analyses The oviductal tissue was separately collected at four stages of the estrous cycle, i.e., proestrus, estrus, metestrus, and diestrus.
ORGANISM(S): Mus musculus 
2012-01-01 | E-GEOD-25875 | biostudies-arrayexpress
TranscriptomicsCancer-Associated Fibroblasts Support Lung Cancer Stemness through Paracrine IGF-II/IGF1R/Nanog Signaling
The CLS1/CAF co-culture maintained the cancer stemness. This cancer stemness was lost when the CAF feeder cells were removed during passaging. To investigate the specific signaling pathways and markers of lung CSCs, we analyzed the gene expression profile of the CLS1 sphere after CLS1/CAF co-cultur...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-38678 | biostudies-arrayexpress
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