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Find the casual relationship between gene expression network and cellular phenotype at single cell resolution. We collected donated human pre-implatation embryos, and the embryonic stem cells derived from them, isolate individual cells, prepared single cell cDNAs, and sequenced them by HiSeq2000. Th...
ORGANISM(S): Homo sapiens 
To identify Dleu2-17aa micropeptide interacting proteins in CD4+ T cells, we performed pull-down assays fllowed by LC-MS using biotin-labeled Dleu2-17aa. As controls, we included the unlabeled free Dleu2-17aa and a biotin-only group. Pull-downs were carried out in both primary mouse CD4+ T cells and...
ORGANISM(S): Mus musculus (Mouse) 
2023-12-23 | PXD046468 | Pride
T Cell stretch-enhancers are vulnerable to Jak inhibitor tofacitinib Treatment of T cells with the Janus kinase (JAK) inhibitor, tofacitinib, disproportionately altered the expression of RA risk genes with stretech-enhancer (SE) structures.
ORGANISM(S): Homo sapiens 
Immune elimination of chronic infection or cancer requires cytotoxic CD8 T cells that adopt and maintain an effector phenotype. Cytotoxic T cell function is a bioenergetically demanding process and T cells subjected to chronic antigen exposure have compromised effector function despite high rates of...
ORGANISM(S): Mus musculus (Mouse) 
2026-10-26 | PXD066950 | Pride
To identify any differentially expressed miRNAs in the CD4+ T cells of lupus. MicroRNAs (miRNAs) have been implicated as fine-tuning regulators controlling diverse biological processes at the level of posttranscriptional repression. Dysregulation of miRNAs has been described in various disease stat...
ORGANISM(S): Mus musculus 
To clarify the expression of relevant proteins in T cells, we conducted a proteomic analysis
ORGANISM(S): Homo Sapiens 
2025-12-04 | PXD071622 |
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