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TranscriptomicsLiver-derived IGF-I regulates mean life span in mice
In this study we used the cre-loxP recombinase system. All mice were genetically modified in as much as all mice had exon 4 of the IGF-I gene flanked by loxP sites. In the knockouts, Mx-Cre had also been introduced, which results in inactivation of the IGF-I gene specifically in the liver. RNA from ...
ORGANISM(S): Mus musculus 
2011-12-01 | E-MEXP-3026 | biostudies-arrayexpress
TranscriptomicsIsolation and Transcriptome Analyses of Human Erythroid Progenitors: BFU-E and CFU-E
Burst-forming unit-erythroid (BFU-E) and colony-forming unit-erythroid (CFU-E) cells are erythroid progenitors traditionally defined by colony assays. We developed a flow cytometry-based strategy for isolating human BFU-E and CFU-E cells based on the changes in expression of cell surface markers dur...
ORGANISM(S): Homo sapiens 
2014-10-30 | E-GEOD-61566 | biostudies-arrayexpress
TranscriptomicsDifferential gene expression in mutants of Arabidopsis FAX1 compared to wild type
DNA microarray analysis (Affymetrix ATH1 GeneChip) on mutant lines of the gene At-FAX1 (At3g57280) in Arabidopsis thaliana was performed as described in Li et al. (2015). In total we analyzed the following comparisons: (A) flowers: fax1 knockout (n = 5) versus wild type (n = 5); (B) flowers: FAX1 ov...
ORGANISM(S): Arabidopsis thaliana 
2015-02-04 | E-MTAB-3090 | biostudies-arrayexpress
TranscriptomicsTranscript Analysis of E. coli ATCC 35218 suggest a Role of cranberry Juice in Inhibiting the growth of E. coli
Several different mechanisms have been proposed to explain the possible role of cranberries, cranberry juice, and cranberry extracts in inhibiting bacterial growth. In this report, we showed that Escherichia coli showed slower growth rate in response to the presence of cranberry juice in the growth...
ORGANISM(S): Escherichia coli 
2010-11-03 | E-GEOD-12554 | biostudies-arrayexpress
MetabolomicsDissecting Metabolism of Leaf Nodules in Ardisia crenata and Psychotria punctata
Root-microbe interaction and its specialized root nodule structures and functions are well studied. In contrast, leaf nodules harboring microbial endophytes in special glandular leaf structures have only recently gained increased interest as plant-microbe phyllosphere interactions. Here, we applied ...
2021-08-26 | MTBLS2870 | MetaboLights
TranscriptomicsRIP-Seq and RNA-Seq of an RNA-binding protein secreted by Listeria monocytogenes which activates RIG-I signaling
Secreted bacterial RNAs have recently emerged as a novel host-pathogen interaction mode. Naked RNA molecules are highly labile in the extracellular environment and must be protected by packaging into membrane vesicles or into complexes with RNA binding proteins. RNA secretion through membrane vesicl...
ORGANISM(S): Listeria monocytogenes EGD-e 
2019-10-16 | E-MTAB-7665 | biostudies-arrayexpress
ProteomicsHLA-E Presents Glycopeptides from the Mtb Protein MPT32 to Human CD8 T Cells
Infection with Mycobacterium tuberculosis (Mtb), the bacterium that causes Tuberculosis, remains a global health concern. Both classically and non-classically restricted cytotoxic CD8+ T cells are important to the control of Mtb infection. We and others have demonstrated that the non-classical MHC I...
ORGANISM(S): Mycobacterium tuberculosis 
2018-10-26 | PXD005765 | Pride
Mycobacterium tuberculosis Cd8 t cells Hla-e 
TranscriptomicsmicroRNA expression of human periodontal ligament derived stem cell line exposed to 1 microMolar (uM) (-)-nicotine liquid or 1 uM nicotine electronic cigarette vapor extract against untreated control
Nicotine and cigarette smoking have been previously shown to inhibit the differentiation potential and miRNA expression of human periodontal ligament derived stem cells (PDLSCs). Electronic cigarette (EC) vapor also contains nicotine, as well as other non-nicotine compounds, and, like cigarette smok...
ORGANISM(S): Homo sapiens 
2019-09-30 | E-MTAB-7893 | biostudies-arrayexpress
TranscriptomicsExpression data from hepatitis E virus inoculated PLC/PRF/5 cells
Hepatitis E virus (HEV) is an important causative pathogen of acute hepatitis. Because of the absence of an in vitro culture system for HEV, research has been greatly impeded. And interaction between HEV and host cells was mainly studied by tansfection/transinfection system, such as Adeno virus tran...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-53731 | biostudies-arrayexpress
TranscriptomicsInterleukin-7 promotes monocyte/macrophage arrest on endothelial cells
Background: It is recognized that atherosclerosis can regresses at least in animal models. However, little is known about the mechanisms. We induced regression of advanced atherosclerosis in apolipoprotein E deficient (APOE­/­) mice and studied underlying mechanisms. Unexpectedly, our study led to t...
ORGANISM(S): Mus musculus 
2009-10-01 | E-GEOD-15914 | biostudies-arrayexpress
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