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ProteomicsStructural mechanism of γ-carboxylation coupled to vitamin K epoxidation at membrane interface
Hemostasis and various non-hemostatic physiologies require γ-carboxylation of designated glutamates in vitamin K-dependent proteins (VKDPs), a process coupled with epoxidation of vitamin K hydroquinone (KH2) by membrane-integrated γ-carboxylase (VKGC). To understand this unique biochemistry, we dete...
ORGANISM(S): Homo sapiens (Human) 
2025-12-22 | PXD052939 | Pride
Factor ix Vitamin k epoxide Vkgc Fix Γ-carboxylation Tmg2 
ProteomicsMolecular basis of vitamin K driven γ-carboxylation at membrane interface
The γ-carboxylation of glutamate residues enables Ca2+-mediated membrane assembly of protein complexes that support broad physiological functions including hemostasis, calcium homeostasis, immune response, and endocrine regulation. Modulating γ-carboxylation level provides prevalent treatments for h...
ORGANISM(S): Homo sapiens (Human) 
2026-01-26 | PXD059315 | Pride
Human Electron microscopy Cryo-em Post-translational modifications Lc-ms/ms 
ProteomicsThe catalytic mechanism of vitamin K epoxide reduction in a cellular environment
Vitamin K epoxide reductases (VKOR) constitute a major family of integral membrane thiol oxidoreductases. In humans, VKOR sustains blood coagulation and bone mineralization through the vitamin K cycle. Previous chemical models assumed that the catalysis of human VKOR (hVKOR) starts from a fully redu...
ORGANISM(S): Homo sapiens (Human) 
2020-12-03 | PXD020676 | Pride
Human vkor Lc/ms/ms Catalytic mechanism 
UnknownCharacterization of Warfarin Inhibition Kinetics Requires Stabilization of Intramembrane Vitamin K Epoxide Reductases.
Not available
S-EPMC7484342 | biostudies-literature
UnknownStabilization and structure determination of integral membrane proteins by termini restraining.
Not available
S-EPMC11649303 | biostudies-literature
UnknownMethods for Structural and Functional Analyses of Intramembrane Prenyltransferases in the UbiA Superfamily.
Not available
S-EPMC5432130 | biostudies-literature
UnknownStructural insights into the vitamin K-dependent γ-carboxylation of osteocalcin.
Not available
S-EPMC12484842 | biostudies-literature
UnknownStructural basis of antagonizing the vitamin K catalytic cycle for anticoagulation.
Not available
S-EPMC7946407 | biostudies-literature
UnknownMolecular basis of vesicular monoamine transport and neurological drug interactions.
Not available
S-EPMC12721464 | biostudies-literature
UnknownStructure of a bacterial homologue of vitamin K epoxide reductase.
Not available
S-EPMC2919313 | biostudies-literature
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