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he unique prolyl isomerase Pin1 that promotes protein conformational changes is a pivotal therapeutic target in many cancers, but little is known about the regulation of Pin1 protein stability. We previously found that Pin1 was highly expressed in glioma stem cells (GSCs) relative to non-stem tumor ...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD041043 | Pride
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Urocitellus parryii 
The metagenome and metabolome data revealed that thioproline treatment significantly altered the gut microbiota community composition and metabolism in CRC mice. These CRC-associated gut microbiota and bacterial metabolites returned to normal levels. Moreover, under thioproline treatment, the microb...
2026-10-16 | MTBLS15941 | MetaboLights
We established an in vivo model of organ-specific colorectal cancer metastasis and demonstrated that the CD110+ tumor initiating cells contribute for colorectal liver metastasis. To gain a deeper understanding of its metastatic capacity, we performed a genome-wide transcriptome analysis on the CD11...
ORGANISM(S): Homo sapiens 
The overall aroma is an important factor of the sensory quality of fruit wines, which attributed to hundreds of volatile compounds. However, the qualitative determination of trace volatile compounds is considered to be very challenging work. GC-Orbitrap-MS with high resolution and high sensitivity p...
2022-08-12 | MTBLS3840 | MetaboLights
miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cel...
ORGANISM(S): Urocitellus parryii 
miRNAs are 19-25 nucleotides long small RNAs now well-known for their regulatory roles in the development and diseases through post-transcriptional and translational controls in a wide range of species. Mammalian hibernation is a physiological process involving dramatic metabolic suppression and cel...
ORGANISM(S): Urocitellus parryii 
ARF1-Flag and its palmitoylation-deficient mutant (C159A-Flag) were purified by immunoprecipitation separately. The purified proteins were digested and analyzed by LC-MS-based quantitative proteomics to identify differential interactors and binding affinity changes induced by ARF1 palmitoylation. Th...
ORGANISM(S): Mus Musculus 
2026-04-27 | PXD072413 |
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